Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Nat Rev Genet. 2023 Mar;24(3):143-160. doi: 10.1038/s41576-022-00534-0. Epub 2022 Oct 19.
N-Methyladenosine (mA) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of mA on mRNA fate and ribosomal RNA function, and have uncovered novel functional roles in virtually every species of RNA. In this Review, we explore the latest studies revealing roles for mA-modified RNAs in chromatin architecture, transcriptional regulation and genome stability. We also summarize mA functions in biological processes such as stem-cell renewal and differentiation, brain function, immunity and cancer progression.
N6-甲基腺苷(m6A)是转录组中最丰富的修饰之一,存在于所有生命领域的细胞 RNA 中。检测和作图方法的进步提高了我们对 m6A 对 mRNA 命运和核糖体 RNA 功能影响的理解,并在几乎所有 RNA 物种中发现了新的功能作用。在这篇综述中,我们探讨了最新的研究成果,这些成果揭示了 m6A 修饰 RNA 在染色质结构、转录调控和基因组稳定性中的作用。我们还总结了 m6A 在干细胞更新和分化、大脑功能、免疫和癌症进展等生物学过程中的功能。