Ying Yibo, Huang Zhiyang, Tu Yurong, Wu Qiuji, Li Zhaoyu, Zhang Yifan, Yu Huilei, Zeng Annian, Huang Hanzhi, Ye Jiahui, Ying Weiyang, Chen Min, Feng Zhiyi, Xiang Ziyue, Ye Qingsong, Zhu Sipin, Wang Zhouguang
School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Bioact Mater. 2022 Oct 11;22:274-290. doi: 10.1016/j.bioactmat.2022.09.019. eCollection 2023 Apr.
Spinal cord injury (SCI) is a serious clinical disease. Due to the deformability and fragility of the spinal cord, overly rigid hydrogels cannot be used to treat SCI. Hence, we used TPA and Laponite to develop a hydrogel with shear-thinning ability. This hydrogel exhibits good deformation, allowing it to match the physical properties of the spinal cord; additionally, this hydrogel scavenges ROS well, allowing it to inhibit the lipid peroxidation caused by ferroptosis. According to the studies, the TPA@Laponite hydrogel could synergistically inhibit ferroptosis by improving vascular function and regulating iron metabolism. In addition, dental pulp stem cells (DPSCs) were introduced into the TPA@Laponite hydrogel to regulate the ratios of excitatory and inhibitory synapses. It was shown that this combination biomaterial effectively reduced muscle spasms and promoted recovery from SCI.
脊髓损伤（SCI）是一种严重的临床疾病。由于脊髓的可变形性和脆弱性，过于刚性的水凝胶不能用于治疗SCI。因此，我们使用三苯基乙酸（TPA）和锂皂石来开发一种具有剪切变稀能力的水凝胶。这种水凝胶表现出良好的变形能力，使其能够与脊髓的物理特性相匹配；此外，这种水凝胶具有良好的清除活性氧（ROS）的能力，使其能够抑制铁死亡引起的脂质过氧化。根据研究，TPA@锂皂石水凝胶可以通过改善血管功能和调节铁代谢来协同抑制铁死亡。此外，将牙髓干细胞（DPSCs）引入TPA@锂皂石水凝胶中以调节兴奋性和抑制性突触的比例。结果表明，这种复合生物材料有效地减少了肌肉痉挛并促进了脊髓损伤的恢复。
