Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Alfaisal University, College of Medicine, Riyadh, Saudi Arabia.
Int J Clin Pract. 2022 Sep 20;2022:8635254. doi: 10.1155/2022/8635254. eCollection 2022.
Children's dental health has become the main concern, due to the increase in caries prevalence amongst children. Pit and fissure sealant (PFS) and fluoride varnish (FV) are effective measures for preventing dental caries. However, the clinical efficacy of these interventions when compared to one another is uncertain. The aim of the present systematic review with meta-analysis was to compare pit and fissure sealants with fluoride varnish for caries prevention of first permanent molars among schoolchildren. This is a meta-Analysis, which involves randomized control trials that compare the effectiveness of PFS with FV within 24 months of follow-up. Five databases were searched from 1990 to 2019 to identify studies published in Arabic or English language. The risk ratio (RR) and 95% confidence intervals (CIs) were calculated using a random-effects model. A total number of 4 studies were included with overall of 1249 children in both groups. Three included trial reported caries increment of first permanent molars (FPM) with 24 months of follow-up, there was no statistical significance (RR: 0.65; 95% CI 0.31 to 1.35; = 0.26 I2 = 89%). As regards DMFS increment, the analysis showed no statistical differences between FV and PFS in terms of lowering DMFS increment (MD: 0.09; 95% CI: -0.03 to 0.21). Findings of this meta-analysis proved there is no significant difference between PFS and FV in caries prevention efficacy of FPMs at 2 years' follow-up, emphasizing the use of FV since it is more affordable and easier to apply.
儿童的口腔健康已成为主要关注点，因为儿童龋齿患病率有所增加。窝沟封闭（PFS）和氟化物涂料（FV）是预防龋齿的有效措施。然而，这些干预措施相互比较的临床效果尚不确定。本系统评价和荟萃分析的目的是比较窝沟封闭剂和氟化物涂料在预防学龄儿童第一恒磨牙龋齿方面的效果。这是一项荟萃分析，涉及在 24 个月的随访期内比较 PFS 和 FV 有效性的随机对照试验。从 1990 年到 2019 年，共搜索了 5 个数据库，以确定用阿拉伯语或英语发表的研究。使用随机效应模型计算风险比（RR）和 95%置信区间（CI）。共纳入 4 项研究，每组共 1249 名儿童。3 项纳入的试验报告了 24 个月随访时第一恒磨牙（FPM）的龋齿增量，无统计学意义（RR：0.65；95%CI 0.31 至 1.35；=0.26 I2=89%）。关于 DMFS 增量，分析表明 FV 和 PFS 在降低 DMFS 增量方面没有统计学差异（MD：0.09；95%CI：-0.03 至 0.21）。这项荟萃分析的结果表明，在 2 年随访时，PFS 和 FV 在预防 FPM 龋齿方面没有显著差异，强调使用 FV，因为它更经济实惠且更容易应用。
