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从物理学角度理解髓鞘II：髓鞘发育的物理起源

A physical perspective to understand myelin II: The physical origin of myelin development.

作者信息

Liu Yonghong, Yue Wenji, Yu Shoujun, Zhou Tian, Zhang Yapeng, Zhu Ran, Song Bing, Guo Tianruo, Liu Fenglin, Huang Yubin, Wu Tianzhun, Wang Hao

机构信息

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, China.

Key Laboratory of Health Bioinformatics, Chinese Academy of Sciences, Shenzhen, China.

出版信息

Front Neurosci. 2022 Oct 3;16:951998. doi: 10.3389/fnins.2022.951998. eCollection 2022.

DOI:10.3389/fnins.2022.951998
PMID:36263368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9574017/
Abstract

The physical principle of myelin development is obtained from our previous study by explaining Peter's quadrant mystery: an externally applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath, respectively. In this study, this principle is considered as a fundamental hypothesis, named Hypothesis-E, to explain more phenomena about myelin development systematically. Specifically, the g-ratio and the fate of the Schwann cell's differentiation are explained in terms of the E-field. Moreover, an experiment is proposed to validate this theory.

摘要

髓鞘发育的物理原理源自我们之前的研究，该研究解释了彼得象限之谜：外部施加的负电场和正电场可分别促进和抑制髓鞘内舌的生长。在本研究中，这一原理被视为一个基本假设，即假设-E，用于系统地解释更多关于髓鞘发育的现象。具体而言，从电场的角度解释了g比值和雪旺细胞分化的命运。此外，还提出了一个实验来验证这一理论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/f46761d6f0a1/fnins-16-951998-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/da600c354418/fnins-16-951998-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/2fc454c9b700/fnins-16-951998-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/09b4d95a6dcc/fnins-16-951998-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/4568dc1f2a18/fnins-16-951998-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/5daef4942ee8/fnins-16-951998-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/3c845fad0035/fnins-16-951998-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/490446e7bdfa/fnins-16-951998-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/34f3c01bf91c/fnins-16-951998-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/f0962d01490b/fnins-16-951998-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/fabc10ef7cd5/fnins-16-951998-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/9edd03551bca/fnins-16-951998-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/b0efbfe2dff5/fnins-16-951998-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/f46761d6f0a1/fnins-16-951998-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/da600c354418/fnins-16-951998-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/2fc454c9b700/fnins-16-951998-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/09b4d95a6dcc/fnins-16-951998-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/4568dc1f2a18/fnins-16-951998-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/5daef4942ee8/fnins-16-951998-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/3c845fad0035/fnins-16-951998-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/490446e7bdfa/fnins-16-951998-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/34f3c01bf91c/fnins-16-951998-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/f0962d01490b/fnins-16-951998-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/fabc10ef7cd5/fnins-16-951998-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/9edd03551bca/fnins-16-951998-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/b0efbfe2dff5/fnins-16-951998-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fef0/9574017/f46761d6f0a1/fnins-16-951998-g013.jpg

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引用本文的文献

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A physical perspective to understand myelin. I. A physical answer to Peter's quadrant mystery.从物理学角度理解髓磷脂。一、对彼得象限之谜的物理学解答。
Front Neurosci. 2022 Sep 26;16:951942. doi: 10.3389/fnins.2022.951942. eCollection 2022.

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Front Neural Circuits. 2021 Jan 18;14:562005. doi: 10.3389/fncir.2020.562005. eCollection 2020.
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Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33649-33659. doi: 10.1073/pnas.2012533117. Epub 2020 Dec 21.
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Oligodendrogenesis increases in hippocampal grey and white matter prior to locomotor or memory impairment in an adult mouse model of tauopathy.
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