Kolokotroni Ourania, Papadopoulou Anna, Middleton Nicos, Kouta Christiana, Raftopoulos Vasilios, Nicolaidou Polyxeni, Yiallouros Panayiotis K
Cyprus International Institute for Environmental & Public Health in association with Harvard School of Public Health, Cyprus University of Technology, Limassol, Cyprus.
Department of Nursing, School of Health Sciences, Cyprus University of Technology, Limassol, Cyprus.
BMC Public Health. 2015 Jan 31;15:48. doi: 10.1186/s12889-015-1385-2.
Emerging evidence suggests that vitamin D might be implicated in asthma pathophysiology. This study aims to compare Vitamin D mean serum levels and status between asthmatic and non-asthmatic adolescents and investigate the association of vitamin D with asthma severity.
In a cohort of adolescents aged 16-17 years, those reporting wheezing in the past 12 months and Ever asthma on the ISAAC questionnaire were invited to participate and formed the Active Asthmatics group. Controls were selected amongst Never Wheezers/Never Asthmatics (NWNA). Differences in mean 25(OH)D serum levels and vitamin D status between AA and NWNA were examined in multivariate linear and logistic regression models respectively, adjusting for potential confounders. Within AA, differences in vitamin D levels were assessed across asthma severity indicators.
A total of 69 AA and 671 NWNA participated in the study. Unadjusted mean 25(OH)D serum levels were 22.90 (SD 6.41), and 21.15 (SD 5.59) ng/mL in NWNA and AA respectively (p = 0.03). In adjusted models, mean 25(OH)D levels remained significantly lower amongst AA compared to NWNA (adjusted beta coefficient -1.68, 95% CI -3.24, -0.13). Severe (<12 ng/mL), moderate (<25 ng/mL) or insufficient (<30 ng/mL) vitamin D status was more prevalent among AA who were 1.6 times (95% CI 1.01, 2.53) more likely to belong to a lower vitamin D category compared to NWNA. Within AA, there was a negative trend between vitamin D levels and the number of reported asthma severity indicators.
Levels of vitamin D tend to be lower among asthmatic compared to non-asthmatic children and in those with severe asthma independent of important confounders.
新出现的证据表明，维生素D可能与哮喘的病理生理学有关。本研究旨在比较哮喘青少年和非哮喘青少年的维生素D平均血清水平及状态，并调查维生素D与哮喘严重程度的关联。
在一组16 - 17岁的青少年中，邀请那些在过去12个月内报告有喘息症状且在国际儿童哮喘和过敏研究（ISAAC）问卷中曾患哮喘的青少年参与，组成活动性哮喘组。对照组从从未喘息/从未患哮喘者（NWNA）中选取。分别在多变量线性和逻辑回归模型中检查活动性哮喘组和从未喘息/从未患哮喘组之间25(OH)D血清平均水平和维生素D状态的差异，并对潜在混杂因素进行调整。在活动性哮喘组内，根据哮喘严重程度指标评估维生素D水平的差异。
共有69名活动性哮喘组患者和671名从未喘息/从未患哮喘组患者参与了研究。未调整的25(OH)D血清平均水平在从未喘息/从未患哮喘组中为22.90（标准差6.41）ng/mL，在活动性哮喘组中为21.15（标准差5.59）ng/mL（p = 0.03）。在调整后的模型中，与从未喘息/从未患哮喘组相比，活动性哮喘组的25(OH)D平均水平仍然显著较低（调整后的β系数为 -1.68，95%置信区间为 -3.24，-0.13）。严重（<12 ng/mL）、中度（<25 ng/mL）或不足（<30 ng/mL）的维生素D状态在活动性哮喘组中更为普遍，与从未喘息/从未患哮喘组相比，前者属于较低维生素D类别的可能性高1.6倍（95%置信区间为1.01，2.53）。在活动性哮喘组内，维生素D水平与报告的哮喘严重程度指标数量之间存在负相关趋势。
与非哮喘儿童相比，哮喘儿童的维生素D水平往往较低，且在患有严重哮喘的儿童中也是如此，这与重要的混杂因素无关。
