The Institute of Molecular and Translational Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710049, China.
Department of Thoracic Surgery, Ruyang People's Hospital, Luoyang 471200, China.
Oncotarget. 2022 Oct 19;13:1136-1139. doi: 10.18632/oncotarget.28301.
In the study of "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers" which was published earlier in Nature Communications, the authors have identified a novel KEAP1/NRF2 target gene, , and demonstrated that plays an essential role in NRF2-mediated ferroptosis resistance and radioresistance in KEAP1-deficient lung cancer cells. Currently, many NRF2 target genes have been found to participate in the regulation of ferroptosis, and exactly which one plays a dominant role seems unclear. This study proposes that is the key effector in NRF2-mediated ferroptosis resistance and radioresistance in KEAP-deficient lung cancer cells, as we discussed in the manuscript.
在 Nature Communications 上早些时候发表的研究“靶向 CoQ-FSP1 轴驱动 KEAP1 失活肺癌中的铁死亡和辐射抗性”中，作者鉴定了一个新的 KEAP1/NRF2 靶基因 ，并表明 在 KEAP1 缺陷型肺癌细胞中 NRF2 介导的铁死亡抗性和放射抗性中发挥重要作用。目前，已经发现许多 NRF2 靶基因参与铁死亡的调节，但具体哪个基因起主导作用尚不清楚。正如我们在论文中讨论的那样，本研究提出 在 KEAP1 缺陷型肺癌细胞中， 是 NRF2 介导的铁死亡抗性和放射抗性的关键效应因子。
