College of Pharmacy, Yanbian University Hospital, Yanbian University, Yanji, 133002, P. R. China.
Cell Death Dis. 2024 Nov 18;15(11):841. doi: 10.1038/s41419-024-07224-1.
Ferroptosis is a distinctive process of cellular demise that is linked to amino acid metabolism, lipid oxidation, and iron oxidation. The ferroptosis cascade genes, which are closely associated with the onset of lung diseases, are among the regulatory targets of nuclear factor erythroid 2-related factor 2 (Nrf2). Although the regulation of ferroptosis is mostly mediated by Nrf2, the precise roles and underlying regulatory mechanisms of ferroptosis and Nrf2 in lung illness remain unclear. This review provides new insights from recent discoveries involving the modulation of Nrf2 and ferroptosis in a range of lung diseases. It also systematically describes regulatory mechanisms involving lipid peroxidation, intracellular antioxidant levels, ubiquitination of Nrf2, and expression of FSP1 and GPX4. Finally, it summarises active ingredients and drugs with potential for the treatment of lung diseases. With the overarching aim of expediting improvements in treatment, this review provides a reference for novel therapeutic mechanisms and offers suggestions for the development of new medications for a variety of lung disorders.
铁死亡是一种与氨基酸代谢、脂质氧化和铁氧化有关的细胞死亡方式。铁死亡级联基因与肺部疾病的发生密切相关，是核因子红细胞 2 相关因子 2 (Nrf2) 的调控靶点之一。尽管铁死亡的调控主要是通过 Nrf2 介导的，但铁死亡和 Nrf2 在肺部疾病中的确切作用和潜在调节机制仍不清楚。本综述从最近的发现中提供了新的见解，涉及 Nrf2 和铁死亡在一系列肺部疾病中的调节。它还系统地描述了涉及脂质过氧化、细胞内抗氧化水平、Nrf2 的泛素化和 FSP1 和 GPX4 的表达的调节机制。最后，它总结了具有治疗肺部疾病潜力的有效成分和药物。本综述旨在为新的治疗机制提供参考，并为各种肺部疾病的新药物开发提供建议，以加速治疗的改进。
