IVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Shmu'el Bait St 12, 9103102, Jerusalem, Israel.
Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
J Assist Reprod Genet. 2022 Nov;39(11):2625-2633. doi: 10.1007/s10815-022-02633-7. Epub 2022 Oct 20.
To report outcome of planned oocyte cryopreservation (POC) in the first 8 years of this treatment in our center.
A retrospective study in a university-affiliated medical center.
A total of 446 women underwent POC during 2011-2018. Fifty-seven (13%) women presented to use these oocytes during the study period (until June 2021). POC was performed at a mean age of 37.9 ± 2.0 (range 33-41). Age at thawing was 43.3 ± 2.1 (range 38-49). A total of 34 (60%) women transferred their oocytes for thawing at other units. Oocyte survival after thawing was significantly higher at our center than following shipping to ancillary sites (78 vs. 63%, p = 0.047). Forty-nine women completed their treatment, either depleting their cryopreserved oocytes without conceiving (36) or attaining a live birth (13)-27% live birth rate per woman. Only one of eleven women who cryopreserved oocytes aged 40 and older had a live birth using thawed oocytes.
Women should be advised to complete planned oocyte cryopreservation before age 40, given low success rates in women who underwent cryopreservation at advanced reproductive age. In this study, oocyte shipping was associated with lower survival rate. These findings may be relevant for women considering POC and utilization of cryopreserved oocytes.
报告本中心首例卵母细胞冷冻保存（POC）治疗 8 年内的结果。
这是一项在大学附属医院进行的回顾性研究。
2011 年至 2018 年间，共有 446 名女性接受了 POC。在研究期间（截至 2021 年 6 月），有 57 名（13%）女性使用这些卵母细胞。POC 的平均年龄为 37.9±2.0 岁（范围 33-41 岁）。解冻时的年龄为 43.3±2.1 岁（范围 38-49 岁）。共有 34 名（60%）女性将其解冻的卵母细胞转移到其他单位进行移植。解冻后卵母细胞的存活率在本中心显著高于运往辅助站点的存活率（78%比 63%，p=0.047）。49 名女性完成了治疗，要么耗尽了冷冻的卵母细胞而未怀孕（36 名），要么实现了活产（13 名）-每名女性的活产率为 27%。在年龄在 40 岁及以上的 11 名冷冻卵母细胞的女性中，只有 1 名使用解冻的卵母细胞实现了活产。
鉴于高龄女性行 POC 治疗的成功率较低，应建议女性在 40 岁之前完成计划的卵母细胞冷冻保存。在本研究中，卵母细胞运输与较低的存活率相关。这些发现可能与考虑 POC 治疗和使用冷冻卵母细胞的女性有关。
