Kakkar Pragati, Geary Joanna, Stockburger Tania, Kaffel Aida, Kopeika Julia, El-Toukhy Tarek
Assisted Conception Unit, Guy's and St Thomas' Hospital NHS Foundation Trust, London SE1 9RT, UK.
J Clin Med. 2023 Jun 21;12(13):4182. doi: 10.3390/jcm12134182.
The purpose of this study is to evaluate the live birth outcome following oocyte thaw in women who underwent social egg freezing at Guy's Hospital, alongside a detailed published literature review to compare published results with the current study. A retrospective cohort study was conducted between January 2016 and March 2022 for all women who underwent egg freezing during this period. Overall, 167 women had 184 social egg freezing cycles. The mean age at freeze was 37.1 years and an average of 9.5 eggs were frozen per retrieval. In total, 16% of the women returned to use their frozen eggs. The mean egg thaw survival rate post egg thaw was 74%. The mean egg fertilisation rate was 67%. The pregnancy rate achieved per embryo transfer was 48% and the live birth rate per embryo transfer was 35%. We also noted that irrespective of age at freezing, a significantly high live birth rate was achieved when the number of eggs frozen per patient was 15 or more. Despite the rapid increase in social egg freezing cycles, the utilisation rate remains low. Pregnancy and live birth rate post thaw are encouraging if eggs are frozen at a younger age and if 15 eggs or more were frozen per patient.
本研究的目的是评估在盖伊医院接受社会卵子冷冻的女性解冻卵母细胞后的活产结局，并进行详细的文献综述，以将已发表的结果与当前研究进行比较。对2016年1月至2022年3月期间所有接受卵子冷冻的女性进行了一项回顾性队列研究。总体而言，167名女性进行了184个社会卵子冷冻周期。冷冻时的平均年龄为37.1岁，每次取卵平均冷冻9.5枚卵子。共有16%的女性回来使用她们冷冻的卵子。解冻后卵母细胞的平均解冻存活率为74%。平均卵子受精率为67%。每次胚胎移植的妊娠率为48%，每次胚胎移植的活产率为35%。我们还注意到，无论冷冻时的年龄如何，当每位患者冷冻的卵子数量为15枚或更多时，活产率都显著较高。尽管社会卵子冷冻周期迅速增加，但利用率仍然很低。如果在较年轻时冷冻卵子，且每位患者冷冻15枚或更多卵子，解冻后的妊娠率和活产率是令人鼓舞的。
