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酷似转移性黑色素瘤的细胞性蓝痣:一例与区域淋巴结痣细胞聚集相关的异常大病灶的报告。

Cellular blue nevus simulating metastatic melanoma: report of an unusually large lesion associated with nevus-cell aggregates in regional lymph nodes.

作者信息

Sterchi J M, Muss H B, Weidner N

出版信息

J Surg Oncol. 1987 Sep;36(1):71-5. doi: 10.1002/jso.2930360117.

DOI:10.1002/jso.2930360117
PMID:3626565
Abstract

A young Caucasian woman had a large area of blue-gray discoloration on the flank and palpable axillary lymph nodes. The discolored area had enlarged during a recent pregnancy, contained multiple subcutaneous nodules, demonstrated increased cellularity and mitotic activity, and was associated with an axillary lymph node containing black streaks within the capsule. Although the lesion was initially considered to be a metastatic malignant melanoma, re-evaluation showed it to be a benign cellular blue nevus with benign nevus-cell aggregates within a regional lymph node. We report this case to emphasize how cellular blue nevus can simulate malignant melanoma and to increase physician awareness of this benign variant of melanocytic nevus so that inappropriate surgery and chemotherapy can be avoided.

摘要

一名年轻的白种女性侧腹有一大片蓝灰色色素沉着区域,且腋窝淋巴结可触及。该色素沉着区域在近期妊娠期间增大,包含多个皮下结节,细胞增多且有丝分裂活性增加,同时伴有一个腋窝淋巴结,其包膜内有黑色条纹。尽管该病变最初被认为是转移性恶性黑色素瘤,但重新评估显示它是一个良性细胞性蓝痣,区域淋巴结内有良性痣细胞聚集。我们报告此病例以强调细胞性蓝痣如何能模拟恶性黑色素瘤,并提高医生对这种黑素细胞痣良性变体的认识,从而避免不适当的手术和化疗。

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Cellular blue nevus simulating metastatic melanoma: report of an unusually large lesion associated with nevus-cell aggregates in regional lymph nodes.酷似转移性黑色素瘤的细胞性蓝痣:一例与区域淋巴结痣细胞聚集相关的异常大病灶的报告。
J Surg Oncol. 1987 Sep;36(1):71-5. doi: 10.1002/jso.2930360117.
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Malignant melanoma primary in lymph node. The case of the missing link.原发性淋巴结恶性黑色素瘤。缺失环节的病例。
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Case of nodal nevus with melanocytic cell aggregates in the lymphatic hilum: A potential diagnostic pitfall that requires differentiation from metastatic melanoma of the lymph node.伴有淋巴管门部黑素细胞聚集的结节性痣病例:一个需要与淋巴结转移性黑色素瘤相鉴别的潜在诊断陷阱。
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Nodal melanocytic nevus with balloon-cell change (nodal balloon-cell nevus).伴有气球样细胞改变的结节性黑素细胞痣(结节性气球样细胞痣)
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Nevus cell aggregates associated with lymph nodes: estimated frequency and clinical significance.与淋巴结相关的痣细胞聚集体:估计频率及临床意义。
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Pigmentation of axillary sentinel nodes from extensive skin tattoo mimics metastatic melanoma: case report.广泛皮肤纹身导致腋窝前哨淋巴结色素沉着酷似转移性黑色素瘤:病例报告
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引用本文的文献

1
Nevus Blue as a Sporadic Finding in a Patient with a Blue Toe?蓝色痣作为蓝趾患者的偶发表现?
Open Access Maced J Med Sci. 2018 May 15;6(5):855-858. doi: 10.3889/oamjms.2018.228. eCollection 2018 May 20.
2
Unusual histologic and clinical variants of melanoma: implications for therapy.黑色素瘤的罕见组织学和临床变体:对治疗的影响。
Curr Oncol Rep. 2007 Sep;9(5):403-10. doi: 10.1007/s11912-007-0055-7.
3
Unusual histologic and clinical variants of melanoma: implications for therapy.黑色素瘤的罕见组织学和临床变体:对治疗的影响。
Curr Treat Options Oncol. 2006 May;7(3):169-80. doi: 10.1007/s11864-006-0010-0.
4
Immunostaining for the tumour suppressor gene p16 product is a useful marker to differentiate melanoma metastasis from lymph-node nevus.肿瘤抑制基因p16产物的免疫染色是区分黑色素瘤转移与淋巴结痣的有用标志物。
Virchows Arch. 2003 Dec;443(6):745-51. doi: 10.1007/s00428-003-0897-9. Epub 2003 Oct 24.