Shenoy B V, Fort L, Benjamin S P
Am J Surg Pathol. 1987 Feb;11(2):140-6. doi: 10.1097/00000478-198702000-00008.
When malignant melanoma occurs in a lymph node, it is presumed to be metastatic, and the primary cutaneous/mucosal process is discovered to be either active, spontaneously regressed, previously excised, or occult. Nevus cell aggregates and nodal blue nevi are well-documented morphologic curiosities occurring in lymph nodes. It has been hypothesized that these nevus cell aggregates and blue nevi could be progenitors of lymph nodal malignant melanoma in patients without an obvious extranodal site of origin. We document a prototypical case of primary malignant melanoma evolving from precursor nevus cell aggregates associated with blue nevi in an axillary lymph node. The coexistence of nodal blue nevi and nevus cell aggregates implies a common origin from migratory neural crest cells arrested within mesenchyme.
当恶性黑色素瘤发生于淋巴结时，一般认为是转移性的，且原发性皮肤/黏膜病变可能处于活动期、已自发消退、先前已切除或隐匿未被发现。痣细胞聚集体和淋巴结蓝色痣是在淋巴结中出现的形态学上已被充分记录的罕见情况。有假说认为，在没有明显淋巴结外起源部位的患者中，这些痣细胞聚集体和蓝色痣可能是淋巴结恶性黑色素瘤的前身。我们记录了一例典型病例，原发性恶性黑色素瘤由腋窝淋巴结中与蓝色痣相关的前体痣细胞聚集体演变而来。淋巴结蓝色痣和痣细胞聚集体的共存意味着它们共同起源于停滞在间充质内的迁移神经嵴细胞。
