Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea.
Alzheimers Res Ther. 2022 Oct 20;14(1):157. doi: 10.1186/s13195-022-01099-0.
The standard Centiloid (CL) method was proposed to harmonize and quantify global F-labeled amyloid beta (Aβ) PET ligands using MRI as an anatomical reference. However, there is need for harmonizing and quantifying regional Aβ uptakes between ligands using CT as an anatomical reference. In the present study, we developed and validated a CT-based regional direct comparison of F-florbetaben (FBB) and F-flutemetamol (FMM) Centiloid (rdcCL).
For development of MRI-based or CT-based rdcCLs, the cohort consisted of 63 subjects (20 young controls (YC) and 18 old controls (OC), and 25 participants with Alzheimer's disease dementia (ADD)). We performed a direct comparison of the FMM-FBB rdcCL method using MRI and CT images to define a common target region and the six regional VOIs of frontal, temporal, parietal, posterior cingulate, occipital, and striatal regions. Global and regional rdcCL scales were compared between MRI-based and CT-based methods. For clinical validation, the cohort consisted of 2245 subjects (627 CN, 933 MCI, and 685 ADD).
Both MRI-based and CT-based rdcCL scales showed that FMM and FBB were highly correlated with each other, globally and regionally (R = 0.960.99). Both FMM and FBB showed that CT-based rdcCL scales were highly correlated with MRI-based rdcCL scales (R = 0.970.99). Regarding the absolute difference of rdcCLs between FMM and FBB, the CT-based method was not different from the MRI-based method, globally or regionally (p value = 0.07~0.95). In our clinical validation study, the global negative group showed that the regional positive subgroup had worse neuropsychological performance than the regional negative subgroup (p < 0.05). The global positive group also showed that the striatal positive subgroup had worse neuropsychological performance than the striatal negative subgroup (p < 0.05).
Our findings suggest that it is feasible to convert regional FMM or FBB rdcSUVR values into rdcCL scales without additional MRI scans. This allows a more easily accessible method for researchers that can be applicable to a variety of different conditions.
标准百分位（CL）方法旨在通过 MRI 作为解剖学参考来协调和量化全球 F 标记的淀粉样蛋白β（Aβ）PET 配体。然而，需要使用 CT 作为解剖学参考来协调和量化配体之间的区域性 Aβ摄取。在本研究中，我们开发并验证了一种基于 CT 的 F-氟比他滨（FBB）和 F-氟美他滨（FMM） Centiloid（rdcCL）的区域直接比较方法。
为了开发基于 MRI 或 CT 的 rdcCL，该队列包括 63 名受试者（20 名年轻对照组（YC）和 18 名老年对照组（OC），以及 25 名阿尔茨海默病痴呆（ADD）患者）。我们使用 MRI 和 CT 图像对 FMM-FBB rdcCL 方法进行了直接比较，以定义一个共同的目标区域和六个区域的额、颞、顶、后扣带回、枕和纹状体区域。比较了基于 MRI 和 CT 的方法之间的全局和区域 rdcCL 标度。为了临床验证，该队列包括 2245 名受试者（627 名 CN、933 名 MCI 和 685 名 ADD）。
基于 MRI 和 CT 的 rdcCL 标度均显示 FMM 和 FBB 之间具有高度相关性，无论是全局还是区域（R = 0.960.99）。FMM 和 FBB 均显示 CT 基于 rdcCL 标度与 MRI 基于 rdcCL 标度高度相关（R = 0.970.99）。关于 FMM 和 FBB 的 rdcCL 之间的绝对差异，CT 基于方法与 MRI 基于方法在全局或区域上没有差异（p 值= 0.07~0.95）。在我们的临床验证研究中，全球负组显示区域阳性亚组的神经心理学表现比区域阴性亚组差（p<0.05）。全球阳性组还显示纹状体阳性亚组的神经心理学表现比纹状体阴性亚组差（p<0.05）。
我们的研究结果表明，无需额外的 MRI 扫描即可将区域 FMM 或 FBB rdcSUVR 值转换为 rdcCL 标度，这为研究人员提供了一种更容易获得的方法，可适用于各种不同的情况。
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