Cho Soo Hyun, Choe Yeong Sim, Kim Hee Jin, Jang Hyemin, Kim Yeshin, Kim Si Eun, Kim Seung Joo, Kim Jun Pyo, Jung Young Hee, Kim Byeong C, Baker Suzanne L, Lockhart Samuel N, Na Duk L, Park Seongbeom, Seo Sang Won
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
Eur J Nucl Med Mol Imaging. 2020 Jul;47(8):1938-1948. doi: 10.1007/s00259-019-04596-x. Epub 2019 Dec 13.
We developed a new method to directly calculate Centiloid (CL) units of F-florbetaben (FBB) and F-flutemetamol (FMM) without conversion to the PiB standardized uptake value ratio (SUVR).
Paired FBB and FMM PET scans were obtained from 20 Alzheimer's disease-related cognitive impairment patients, 16 old controls, and 20 young controls. We investigated the correlations between the FBB and FMM CL units using the direct comparison of FBB-FMM CL (dcCL) method and the standard CL method and compare differences in FBB and FMM CL units between dcCL method and the standard method.
Following the conversion of FBB or FMM SUVRs into CL units, a direct relationship was formed between the FBB or FMM SUVRs and the CL units using dcCL method (FBB dcCL = 151.42 × FBB dcSUVR - 142.24 and FMM dcCL = 148.52 × FMM dcSUVR - 137.09). The FBB and FMM CL units were highly correlated in both our method (R = 0.97, FMM dcCL = 0.97 × FBB dcCL + 1.64) and the standard method (R = 0.97, FMM CLstandard = 0.79 × FBB CLstandard + 1.36). However, the CL variations between FBB and FMM were smaller when calculated by dcCL method (6.15) than when calculated by the previous method (10.22; P = 0.01).
Our findings suggest that our direct comparison of FBB-FMM method, rather than the standard method, is a reasonable way to convert FBB or FMM SUVRs into CL units, at least in environments where FBB or FMM ligands are used frequently.
我们开发了一种新方法，可直接计算F-氟贝他班（FBB）和F-氟代甲磺酸美他莫（FMM）的百分位数（CL）单位，而无需转换为匹兹堡化合物B标准化摄取值比率（SUVR）。
对20例阿尔茨海默病相关认知障碍患者、16例老年对照者和20例年轻对照者进行了FBB和FMM的PET配对扫描。我们使用FBB-FMM CL（dcCL）直接比较法和标准CL法研究了FBB和FMM CL单位之间的相关性，并比较了dcCL法和标准法之间FBB和FMM CL单位的差异。
将FBB或FMM SUVR转换为CL单位后，使用dcCL法在FBB或FMM SUVR与CL单位之间形成了直接关系（FBB dcCL = 151.42 × FBB dcSUVR - 142.24和FMM dcCL = 148.52 × FMM dcSUVR - 137.09）。在我们的方法（R = 0.97，FMM dcCL = 0.97 × FBB dcCL + 1.64）和标准方法（R = 0.97，FMM CLstandard = 0.79 × FBB CLstandard + 1.36）中，FBB和FMM CL单位均高度相关。然而，用dcCL法计算时FBB和FMM之间的CL变化（6.15）比用先前方法计算时（10.22；P = 0.01）更小。
我们的研究结果表明，我们的FBB-FMM直接比较法，而非标准方法，是将FBB或FMM SUVR转换为CL单位的合理方法，至少在频繁使用FBB或FMM配体的环境中如此。
