Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science, Kerman University of Medical Sciences, Kerman, Iran.
Endocrinol Diabetes Metab. 2022 Nov;5(6):e387. doi: 10.1002/edm2.387. Epub 2022 Oct 20.
Cardiovascular diseases are very common in the general population, and several factors play a role in their development. The purpose of this study was to investigate the relationship between hyperuricaemia and other cardiovascular disease risk factors.
This cross-sectional study was conducted on 1008 people over the 15-year-old general population in Kerman, Iran. The blood samples of all patients were analysed for the uric acid serum level, and they completed a checklist including physical activity, previous history of hypertension and diabetes, smoking and opium.
A number of 1008 cases of people were entered into the study. According to the results of this study, 254 patients had uric acid levels above the 75th percentile (6 mg/dl in males, and 5 mg/dl in females). No significant difference was observed between gender (p = .249) and age groups (p = .125) of people with and without hyperuricaemia. The prevalence of overweight/obesity (p < .001), hypertension (p = .004) and low physical activity (p = .033) was significantly higher in patients with hyperuricaemia. The duration of hypertension was significantly higher in hyperuricaemic individuals (p = .022). Overweight/obesity (OR = 2.67; 95% CI = 1.87-3.82) and hypertension (OR = 1.40; 95% CI = 1.02-1.93) were two significant independent factors that contributed to the increased risk of hyperuricaemia in the subjects.
The uric acid serum level is higher in people with hypertension and overweight/obesity. Hyperuricaemia increases the risk of cardiovascular events, which can be prevented by determining the appropriate strategy for the early diagnosis and treatment of this metabolic disorder.
心血管疾病在普通人群中非常常见，有几个因素在其发展中起作用。本研究的目的是探讨高尿酸血症与其他心血管疾病危险因素之间的关系。
这项横断面研究在伊朗克尔曼的 1008 名 15 岁以上的普通人群中进行。对所有患者的血尿酸血清水平进行了分析，并完成了一份包括身体活动、高血压和糖尿病既往史、吸烟和鸦片使用情况的检查表。
共有 1008 例患者纳入研究。根据本研究的结果，254 例患者的尿酸水平高于第 75 百分位数（男性 6mg/dl，女性 5mg/dl）。高尿酸血症患者和无高尿酸血症患者的性别（p=0.249）和年龄组（p=0.125）之间无显著差异。超重/肥胖（p<0.001）、高血压（p=0.004）和低体力活动（p=0.033）的患病率在高尿酸血症患者中显著更高。高尿酸血症患者的高血压持续时间明显更长（p=0.022）。超重/肥胖（OR=2.67；95%CI=1.87-3.82）和高血压（OR=1.40；95%CI=1.02-1.93）是导致研究对象高尿酸血症风险增加的两个显著独立因素。
高血压和超重/肥胖患者的血尿酸水平较高。高尿酸血症会增加心血管事件的风险，可以通过确定适当的策略来早期诊断和治疗这种代谢紊乱来预防。
