Hanno P M, Fritz R, Wein A J, Mulholland S G
Urology. 1978 Oct;12(4):411-5. doi: 10.1016/0090-4295(78)90291-1.
Previous studies performed in our laboratory indicated that the primary antibacterial defense mechanism of the rabbit bladder is the antiadsorptive action of the surface mucopolysaccharide. The increased bacterial adsorption that occurs when the bladder is denuded of this layer was prevented by the instillation of heparin. Additional studies showed that the protective effect of heparin is inhibited by protamine, a further indication that the bladder's "antiadherence factor" is a mucopolysaccharide. Small amounts of heparin, applied directly to the mucoprotein-deficient bladder or to the surface of the inoculated bacteria, produced a statistically significant reduction in bacterial adsorption.
我们实验室之前进行的研究表明，兔膀胱的主要抗菌防御机制是表面粘多糖的抗吸附作用。当膀胱剥去这层物质时发生的细菌吸附增加，可通过注入肝素加以阻止。进一步的研究表明，鱼精蛋白会抑制肝素的保护作用，这进一步表明膀胱的“抗黏附因子”是一种粘多糖。将少量肝素直接应用于缺乏粘蛋白的膀胱或接种细菌的表面，可使细菌吸附在统计学上显著减少。
