Moretta Gaia, Samela Tonia, Sampogna Francesca, Ricci Francesco, Carlesimo Fabio, Panebianco Annarita, D'Erme Angelo Massimiliano, Di Lella Giovanni, Pallotta Sabatino, Dellambra Elena, Abeni Damiano, Fania Luca
IDI-IRCCS, Dermatological Research Hospital, Rome.
Unit of Dermatology, Livorno Hospital, Livorno, Italy.
Dermatol Reports. 2022 Jan 31;14(3):9392. doi: 10.4081/dr.2022.9392. eCollection 2022 Sep 14.
Actinic keratosis (AK) is considered a precancerous lesion that can develop into invasive squamous cell carcinoma. Its prevalence is increasing, and it is estimated that it affects between 1% and 44% of the adult population worldwide. Advanced age, fair skin phototypes, and cumulative sun exposure are the main risk factors for AK. Therapies for AK consists of lesion-directed treatment (, cryotherapy, curettage, electrocoagulation, and laser therapy) or field therapy [, photodynamic therapy (PDT), 5-fluorouracil (5-FU), diclofenac sodium (DIC), imiquimod (IMQ), and ingenol mebutate (Ing Meb)]. The type of therapy chosen is determined by the number and location of AKs, the patient's condition, and the patient's tolerability and compliance. In this survey, we collected information from 110 Italian dermatologists about their knowledge and attitudes toward various AK therapeutic approaches. In our study, we discovered that cryotherapy and PDT are the most used treatments for AK, while surgery and laser therapy are the least commonly used. The most commonly used topical therapies are DIC and IMQ 3.75 percent cream, followed by IMQ 5 percent cream, Ing Meb, and 5-FU. The correct treatment for AK can be difficult to choose, but adherence to therapy is critical for good results. Given the high and continuing rise in the incidence of AK, dermatologists' knowledge of various therapeutic approaches is critical.
光化性角化病(AK)被认为是一种癌前病变,可发展为浸润性鳞状细胞癌。其患病率正在上升,据估计,全球1%至44%的成年人口受其影响。高龄、白皙皮肤光型和累积日晒是AK的主要危险因素。AK的治疗方法包括病变定向治疗(如冷冻疗法、刮除术、电凝术和激光疗法)或区域治疗(如光动力疗法(PDT)、5-氟尿嘧啶(5-FU)、双氯芬酸钠(DIC)、咪喹莫特(IMQ)和鬼臼毒素酯(Ing Meb))。选择的治疗类型取决于AK的数量和位置、患者状况以及患者的耐受性和依从性。在这项调查中,我们收集了110名意大利皮肤科医生关于他们对各种AK治疗方法的知识和态度的信息。在我们的研究中,我们发现冷冻疗法和PDT是AK最常用的治疗方法,而手术和激光疗法使用最少。最常用的局部治疗药物是DIC和3.75%咪喹莫特乳膏,其次是5%咪喹莫特乳膏、Ing Meb和5-FU。AK的正确治疗方法可能难以选择,但坚持治疗对于取得良好效果至关重要。鉴于AK发病率持续大幅上升,皮肤科医生对各种治疗方法的了解至关重要。