Heilongjiang Administration of Traditional Chinese Medicine, Harbin 150000, China.
The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150000, China.
Mediators Inflamm. 2022 Oct 11;2022:6508046. doi: 10.1155/2022/6508046. eCollection 2022.
There has been a significant amount of interest in the past two decades in the study of the evolution of the gut microbiota, its internal and external impacts on the gut, and risk factors for cerebrovascular disorders such as cerebral ischemic stroke. The network of bidirectional communication between gut microorganisms and their host is known as the microbiota-gut-brain axis (MGBA). There is mounting evidence that maintaining gut microbiota homeostasis can frequently enhance the effectiveness of ischemic stroke treatment by modulating immune, metabolic, and inflammatory responses through MGBA. To effectively monitor and cure ischemic stroke, restoring a healthy microbial ecology in the gut may be a critical therapeutic focus. This review highlights mechanistic insights on the MGBA in disease pathophysiology. This review summarizes the role of MGBA signaling in the development of stroke risk factors such as aging, hypertension, obesity, diabetes, and atherosclerosis, as well as changes in the microbiota in experimental or clinical populations. In addition, this review also examines dietary changes, the administration of probiotics and prebiotics, and fecal microbiota transplantation as treatment options for ischemic stroke as potential health benefits. It will become more apparent how the MGBA affects human health and disease with continuing advancements in this emerging field of biomedical sciences.
在过去的二十年中，人们对肠道微生物群的进化、其对肠道的内部和外部影响以及脑血管疾病（如脑缺血性中风）的风险因素产生了浓厚的兴趣。肠道微生物群与其宿主之间的双向交流网络被称为微生物群-肠道-大脑轴（MGBA）。越来越多的证据表明，通过 MGBA 调节免疫、代谢和炎症反应，维持肠道微生物群的平衡可以经常增强缺血性中风治疗的效果。为了有效地监测和治疗缺血性中风，恢复肠道健康的微生物生态可能是一个关键的治疗重点。本综述强调了 MGBA 在疾病病理生理学中的机制见解。本综述总结了 MGBA 信号在中风危险因素（如衰老、高血压、肥胖、糖尿病和动脉粥样硬化）发展中的作用，以及实验或临床人群中微生物群的变化。此外，本综述还探讨了饮食变化、益生菌和益生元的管理以及粪便微生物群移植作为缺血性中风治疗选择的潜在健康益处。随着这一新兴生物医学科学领域的不断发展，MGBA 如何影响人类健康和疾病将变得更加明显。
