Department of Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Department of Internal Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Dis Markers. 2022 Oct 11;2022:1187742. doi: 10.1155/2022/1187742. eCollection 2022.
Preeclampsia (PE) is a common obstetric complication that has caused significant harm to pregnant mothers. The clinical significance of poor nutritional status in PE patients is unclear. The aim of our study was to evaluate the nutritional status as measured by the prognostic nutritional index (PNI) score at admission, and its ability to predict in-hospitalization adverse events in patients with PE.
We enrolled patients diagnosed with PE in the Third Affiliated Hospital of Guangzhou Medical University from January 2019 to December 2021. Patients were divided into low and high nutritional status group according to the cut-off value of PNI score at admission using the receiver operating characteristic (ROC) curve. PNI score were used to explore the relationship between PNI score and in-hospitalization adverse events presented with hazard ratio (HR) and 95% confidence intervals (CI).
A total of 733 patients were included in the study. The proportion of adverse events and admission to intensive care unit (ICU) was higher in the low nutritional status group than in the high nutritional status group ( < 0.05). ROC curve analysis revealed an area under curve (AUC) of 0.628 for PNI score and the cut-off value of PNI was 37. The free-event rates determined by KM analysis were significantly lower in the low nutritional status compared to the high nutritional status ( < 0.05). Adjusted multivariate analysis showed that PNI score was independently associated with favorable outcomes (HR: 2.66; 95% CI: 1.724-4.050, < 0.001).
High PNI score at admission was associated with reduced in-hospitalization risk of adverse events in patients with PE. Additional enhancing nutritional status during hospitalization may help to prevent unfavorable prognosis in clinical practices.
子痫前期（PE）是一种常见的产科并发症，已对孕妇造成严重危害。PE 患者营养状况不良的临床意义尚不清楚。本研究旨在评估入院时预后营养指数（PNI）评分所衡量的营养状况及其预测 PE 患者住院期间不良事件的能力。
我们纳入了 2019 年 1 月至 2021 年 12 月期间在广州医科大学附属第三医院就诊的 PE 患者。根据入院时 PNI 评分的截断值，使用受试者工作特征（ROC）曲线将患者分为低和高营养状态组。使用风险比（HR）和 95%置信区间（CI）来探索 PNI 评分与住院不良事件之间的关系。
本研究共纳入 733 例患者。低营养状态组的不良事件和入住重症监护病房（ICU）的比例高于高营养状态组（<0.05）。ROC 曲线分析显示 PNI 评分的曲线下面积（AUC）为 0.628，截断值为 37。KM 分析确定的无事件生存率在低营养状态组明显低于高营养状态组（<0.05）。多变量调整分析显示，PNI 评分与良好结局独立相关（HR：2.66；95%CI：1.724-4.050，<0.001）。
入院时较高的 PNI 评分与 PE 患者住院期间不良事件风险降低相关。在住院期间额外增强营养状况可能有助于预防临床不良预后。
