Wei Dongmei, Meng Jian, Zhang Yueting, Chen Yueyue, Li Jijie, Niu Xiaoyu
Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Ann Transl Med. 2022 Sep;10(18):965. doi: 10.21037/atm-22-3539.
This study sought to analyze the potential associated factors for female stress urinary incontinence (SUI).
A total of 5,013 women were screened for pelvic floor function at the West China Second Hospital of Sichuan University from January 2015 to January 2019. Of these, 410 patients were diagnosed with SUI. A single-factor Chi-square test and multi-factor logistic regression analysis were conducted to examine the relationship between pre-pregnancy urinary incontinence, vaginal delivery, menopause, and hormone therapy, chronic cough, and smoking, and postpartum SUI.
The postpartum SUI rate in patients with urinary incontinence during pregnancy was 19.33%, while that of patients without urinary incontinence was only 5.44%. The rates of urinary incontinence in patients experiencing vaginal delivery or cesarean delivery were 13.62% and 4.36%, respectively. The SUI incidences in patients with or without a family genetic history of SUI were 28.46% and 7.48%, respectively. The incidence rates of SUI in smoking and non-smoking patients were 18.92% and 8.39%. The rate of SUI in patients with chronic cough (16.46%) behaved significantly differently from those with non-chronic cough (8.21%). The occurrence of SUI was highly correlated with the following factors, including pre-pregnancy urinary incontinence (OR =5.256; 95% CI: 2.061-13.409; P<0.001), urological incontinence during the pregnancy period (OR =2.965; 95% CI: 2.111-4.163; P<0.001), vaginal delivery (OR =4.028; 95% CI: 2.909-5.577; P<0.001), and genetic history (OR =4.341; 95% CI: 2.8-6.73; P<0.001).
The occurrence of SUI is highly related to a history of urinary incontinence, the delivery mode, chronic cough, smoking, and genetic history. Further, urinary incontinence before and during pregnancy, natural delivery, and genetic history are important independent high-associated factors for SUI. Our findings show the importance of screening for the above associated factors in association with SUI.
本研究旨在分析女性压力性尿失禁（SUI）的潜在相关因素。
2015年1月至2019年1月，四川大学华西第二医院对5013名女性进行了盆底功能筛查。其中，410例患者被诊断为SUI。采用单因素卡方检验和多因素逻辑回归分析，以探讨孕前尿失禁、阴道分娩、绝经及激素治疗、慢性咳嗽、吸烟与产后SUI之间的关系。
孕期有尿失禁的患者产后SUI发生率为19.33%，而无尿失禁的患者仅为5.44%。经阴道分娩或剖宫产患者的尿失禁发生率分别为13.62%和4.36%。有或无SUI家族遗传史的患者SUI发生率分别为28.46%和7.48%。吸烟和不吸烟患者的SUI发生率分别为18.92%和8.39%。慢性咳嗽患者的SUI发生率（16.46%）与非慢性咳嗽患者（8.21%）有显著差异。SUI的发生与以下因素高度相关，包括孕前尿失禁（OR =5.256；95%CI：2.061 - 13.409；P<0.001）、孕期尿失禁（OR =2.965；95%CI：2.111 - 4.163；P<0.001）、阴道分娩（OR =4.028；95%CI：2.909 - 5.577；P<0.001）和遗传史（OR =4.341；95%CI：2.8 - 6.73；P<0.001）。
SUI的发生与尿失禁史、分娩方式、慢性咳嗽、吸烟和遗传史高度相关。此外，孕前和孕期尿失禁、自然分娩和遗传史是SUI重要的独立高相关因素。我们的研究结果表明筛查上述与SUI相关因素的重要性。
