Konishi Keisuke, Sakamoto Mei, Satake Chikara, Isaka Mitsuhiro, Okazaki Seiji, Kono Shota, Nakamura Takayuki, Tashiro Hideki, Ushigusa Takahiro
Yokohama Animal Medical Center Kannai Animal Clinic, Yokohama, Japan.
FUJIFILM VET Systems Co., Ltd., Tokyo, Japan.
Front Vet Sci. 2022 Oct 4;9:1008765. doi: 10.3389/fvets.2022.1008765. eCollection 2022.
Perioperative myocardial injury (PMI) is commonly caused by myocardial ischemia that develops during or after non-cardiac surgery. It occurs in 17.9% of human patients after non-cardiac surgery due to elevated high-sensitive perioperation cardiac troponin. However, PMI has not been demonstrated in cats. To investigate its occurrence, this study aimed to analyze the perioperative changes in cardiac biomarkers and clinical data, including measurement of vital signs, echocardiography, blood pressure, electrocardiogram, X-ray, and anesthetic profile, in 30 juvenile cats under neutering surgery. All cats had increased high-sensitive cardiac troponin I (hs-cTnI) postsurgery compared with presurgery. In particular, 48% of cats (14/29) showed elevated hs-cTnI over a reference range after surgery. In all groups, hs-cTnI and systolic arterial blood pressure (SAP) were significantly higher at 0 h and 18 h postoperation than at preoperation. A significant positive correlation was found between hs-cTnI and SAP at 18 h postoperation. Atrial natriuretic peptides, heart rate, and left ventricular wall thickness were markedly higher at 0 h postoperation than at preoperation; however, respiratory rate and body temperature were significantly lower at 0 h postoperation than at preoperation. Anesthetic time and hs-cTnI were significantly higher at 18 h postoperation in females than in males. Significant positive correlations were observed between hs-cTnI and anesthetic time at 18 h postoperation in females. These results indicate that postoperative hs-cTnI level can greatly increase in juvenile cats and hs-cTnI measurement at perioperation is potentially beneficial for early detection and evaluation of the presence of PMI.
围手术期心肌损伤（PMI）通常由非心脏手术期间或术后发生的心肌缺血引起。由于高敏围手术期心肌肌钙蛋白升高，17.9%的非心脏手术患者会出现PMI。然而，PMI在猫身上尚未得到证实。为了研究其发生率，本研究旨在分析30只接受绝育手术的幼年猫围手术期心脏生物标志物的变化和临床数据，包括生命体征测量、超声心动图、血压、心电图、X线和麻醉情况。与术前相比，所有猫术后高敏心肌肌钙蛋白I（hs-cTnI）均升高。特别是，48%的猫（14/29）术后hs-cTnI超过参考范围。在所有组中，术后0小时和18小时的hs-cTnI和收缩期动脉血压（SAP）均显著高于术前。术后18小时，hs-cTnI与SAP之间存在显著正相关。术后0小时的心房利钠肽、心率和左心室壁厚度明显高于术前；然而，术后0小时的呼吸频率和体温明显低于术前。术后18小时，雌性猫的麻醉时间和hs-cTnI显著高于雄性猫。雌性猫术后18小时，hs-cTnI与麻醉时间之间存在显著正相关。这些结果表明，幼年猫术后hs-cTnI水平可大幅升高，围手术期测量hs-cTnI可能有助于早期检测和评估PMI的存在。
