Sardana Ojus, Kumari Pratima, Singh Ravinder, Chopra Hitesh, Emran Talha Bin
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh.
Ann Med Surg (Lond). 2022 Sep 6;82:104504. doi: 10.1016/j.amsu.2022.104504. eCollection 2022 Oct.
Acute pancreatitis (AP) and associated metabolic abnormalities constitute prevalent medical disorders that have disastrous implications and expensive cost of care. However, the connection with metabolic abnormalities and their influence on wellbeing i.e., health-related quality of life (HRQoL) remains unclear. As a result, we investigated the influence of MetS components on HRQoL in AP patients.
In a tertiary care hospital in North India, comprehensive observational research was undertaken with enrollment of subjects having AP along metabolic syndrome (MetS) or without was included. MetS was diagnosed for subjects using the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) guidelines. Various socio-demographic variables were also taken into consideration for the calculation of statistical significance (P ≤ 0.05) in AP patients. Student's -test and Short Form-36 (SF-36) along with the association between AP and MetS, as well as their impact on HRQoL, was investigated finally with, Pearson Correlation Analysis Factor.
The study comprised 100 subjects or patients diseased of AP associated with MetS and 100 patients with AP associated without MetS. Gender, Age, Educational Status, Tobacco uses along with the metabolic variables were found to be statistically significant (P ≤ 0.05) and comparatively increased in patients with AP with MetSthan AP without MetS except HDL levels. Finally, a negative association between all metabolic variables with the exception of HDL, and AP was found to be producing deterioration in Health compartment scores.
AP with MetS patients had a worse aggregate HRQOL than AP without MetS patients.
急性胰腺炎（AP）及相关代谢异常是常见的医学病症，具有灾难性影响且护理成本高昂。然而，与代谢异常的关联及其对健康状况（即健康相关生活质量，HRQoL）的影响仍不明确。因此，我们研究了代谢综合征（MetS）各组分对AP患者HRQoL的影响。
在印度北部的一家三级护理医院开展了一项全面的观察性研究，纳入了患有AP且伴有或不伴有代谢综合征（MetS）的受试者。采用美国国家胆固醇教育计划成人治疗组第三次报告（NCEP-ATP III）指南对受试者进行MetS诊断。在计算AP患者的统计学显著性（P≤0.05）时，还考虑了各种社会人口统计学变量。最后，采用学生t检验和简短健康调查问卷（SF-36）以及Pearson相关分析因子，研究AP与MetS之间的关联及其对HRQoL的影响。
该研究包括100例患有与MetS相关的AP患者和100例不伴有MetS的AP患者。发现性别、年龄、教育程度、吸烟情况以及代谢变量具有统计学显著性（P≤0.05），且与不伴有MetS的AP患者相比，伴有MetS的AP患者中这些因素相对增加，但高密度脂蛋白（HDL）水平除外。最后，发现除HDL外的所有代谢变量与AP之间呈负相关，这会导致健康领域评分下降。
与不伴有MetS的AP患者相比。伴有MetS的AP患者的总体HRQOL更差。
