Ejtahed Hanieh-Sadat, Soroush Mohammad-Reza, Hasani-Ranjbar Shirin, Angoorani Pooneh, Mousavi Batool, Masumi Mehdi, Edjtehadi Farhad, Soveid Mahmood
Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Janbazan Medical and Engineering Research Center (JMERC), Tehran, Iran.
J Diabetes Metab Disord. 2017 Apr 5;16:17. doi: 10.1186/s40200-017-0298-2. eCollection 2017.
Lower limb amputation is correlated with considerable impairments in health-related quality of life (HRQOL) in veterans. The aim of this study is to determine the prevalence of metabolic syndrome (MetS) in veterans with bilateral lower limb amputation and to identify its association with HRQOL.
This cross-sectional study was conducted on 235 Iranian male veterans with bilateral lower limb amputation. Demographics, anthropometrics, and biochemical measurements were assessed and MetS was defined by National Cholesterol Education Program Adult Treatment Panel III definition. HRQOL was assessed using the 36-item Short Form Health Survey (SF-36) questionnaire which measures eight health-related domains. The scores were compared between two groups of bilateral lower limb Amputees who have diagnosed with and without MetS.
The response rate was 40.7% and the mean age of the amputees was 52.05 years. 62.1% of participants were suffering from MetS (95% CI: 55.9%-68.4%). Patients with MetS were observed to have higher weight, waist and hip circumferences, FBS, TG, LDL and liver enzymes concentrations ( < 0.05). Although scores on all 8 subscales of SF-36 were low, no significant difference was observed in HRQOL scores between amputees with and without MetS. Moreover, the risk of MetS was not significantly different across subjects in the highest compared to the lowest quartile category of HRQOL scores.
Prevalence of MetS in veterans with bilateral lower limb amputation was higher and their HRQOL was lower compared to general population. Some strategies are needed to reduce the risk of cardiovascular diseases among this susceptible population.
下肢截肢与退伍军人健康相关生活质量（HRQOL）的显著损害相关。本研究的目的是确定双侧下肢截肢退伍军人中代谢综合征（MetS）的患病率，并确定其与HRQOL的关联。
对235名伊朗男性双侧下肢截肢退伍军人进行了这项横断面研究。评估了人口统计学、人体测量学和生化指标，并根据美国国家胆固醇教育计划成人治疗小组第三次报告的定义来定义MetS。使用36项简短健康调查（SF-36）问卷评估HRQOL，该问卷测量八个与健康相关的领域。比较了两组诊断为患有和未患有MetS的双侧下肢截肢者的得分。
应答率为40.7%，截肢者的平均年龄为52.05岁。62.1%的参与者患有MetS（95%置信区间：55.9%-68.4%）。观察到患有MetS的患者体重、腰围和臀围、空腹血糖、甘油三酯、低密度脂蛋白和肝酶浓度更高（<0.05）。虽然SF-36的所有8个分量表得分都很低，但患有和未患有MetS的截肢者在HRQOL得分上没有观察到显著差异。此外，在HRQOL得分最高四分位数组与最低四分位数组的受试者中，MetS的风险没有显著差异。
与普通人群相比，双侧下肢截肢退伍军人中MetS的患病率更高，他们的HRQOL更低。需要采取一些策略来降低这一易感人群中心血管疾病的风险。
