de Assis Gadelha Danilo Duarte, de Brito Alves José Luiz, da Costa Paulo César Trindade, da Luz Mickael Sousa, de Oliveira Cavalcanti Clênia, Bezerril Fabrícia França, Almeida Juliana Franco, de Campos Cruz Josiane, Magnani Marciane, Balarini Camille Moura, Rodrigues Mascarenhas Sandra, de Andrade Braga Valdir, de França-Falcão Maria do Socorro
Health Sciences Center, Federal University of Paraíba, João Pessoa, PB, Brazil.
Biotechnology Center, Federal University of Paraíba, João Pessoa, PB, Brazil.
Crit Rev Food Sci Nutr. 2024;64(12):3839-3860. doi: 10.1080/10408398.2022.2136618. Epub 2022 Oct 21.
Hypertension is the leading risk factor for cardiovascular diseases and is associated with intestinal dysbiosis with a decrease in beneficial microbiota. Probiotics can positively modulate the impaired microbiota and impart benefits to the cardiovascular system. Among them, the emended has stood out as a microorganism capable of reducing blood pressure, being the target of several studies focused on managing hypertension. This review aimed to present the potential of as an antihypertensive non-pharmacological strategy. We will address preclinical and clinical studies that support this proposal and the mechanisms of action by which these microorganisms reduce blood pressure or prevent its elevation.
高血压是心血管疾病的主要危险因素,与肠道菌群失调及有益微生物群减少有关。益生菌可积极调节受损的微生物群,并对心血管系统产生益处。其中,[具体名称未给出]已成为一种能够降低血压的微生物,成为多项专注于管理高血压研究的目标。本综述旨在介绍[具体名称未给出]作为一种抗高血压非药物策略的潜力。我们将探讨支持这一观点的临床前和临床研究,以及这些微生物降低血压或预防血压升高的作用机制。