Zaidi Syed A H, Caldwell Ruth B, Rojas Modesto A
Vascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Vision Discovery Institute, Augusta University, Augusta, GA, 30912, USA.
NPJ Metab Health Dis. 2025 Jan 13;3(1):2. doi: 10.1038/s44324-024-00046-x.
Pathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and neurovascular injury. We show that OIR-induced activation of macrophage/microglial cells, retinal inflammation, and pathological RNV are mediated by increases in cholesterol ester (CE) formation due to activation of the acyl-CoA: Cholesterol Acyltransferase 1/Sterol O-Acyltransferase 1 (ACAT1/SOAT1) enzyme.
病理性视网膜新生血管形成（RNV）是缺血性视网膜病变导致视力丧失和失明的主要原因。我们在氧诱导性视网膜病变（OIR）小鼠模型中的研究揭示了病理性RNV和神经血管损伤的新机制。我们发现，OIR诱导的巨噬细胞/小胶质细胞激活、视网膜炎症和病理性RNV是由酰基辅酶A：胆固醇酰基转移酶1/固醇O-酰基转移酶1（ACAT1/SOAT1）酶激活导致胆固醇酯（CE）形成增加所介导的。
