以肝活检为“金标准”比较视觉瞬时弹性成像、振动控制瞬时弹性成像、剪切波弹性成像和声学触诊弹性成像在慢性肝病评估中的应用

Comparison of Visual Transient Elastography, Vibration Controlled Transient Elastography, Shear Wave Elastography and Sound Touch Elastography in Chronic liver Disease assessment using liver biopsy as 'Gold Standard'.

作者信息

Gatos Ilias, Yarmenitis Spyros, Theotokas Ioannis, Koskinas John, Manesis Emmanuel, Zoumpoulis Spyros P, Zoumpoulis Pavlos S

机构信息

Diagnostic Echotomography SA, 317C Kifissias Ave., GR 14561, Kifissia, Greece; Department of Medical Physics, School of Medicine, University of Patras, Rion, GR 26504, Greece.

Diagnostic Echotomography SA, 317C Kifissias Ave., GR 14561, Kifissia, Greece.

出版信息

Eur J Radiol. 2022 Dec;157:110557. doi: 10.1016/j.ejrad.2022.110557. Epub 2022 Oct 17.

DOI:10.1016/j.ejrad.2022.110557

PMID:36274360

Abstract

PURPOSE

Chronic liver disease (CLD) is considered one of the main causes of death. Ultrasound Elastography (USE) is a CLD assessment imaging method. This study aims to evaluate a recently introduced commercial alternative of USE, Visual Transient Elastography (ViTE), and to compare it with three established USE methods, Vibration Controlled Transient Elastography (VCTE), Shear Wave Elastography (SWE) and Sound Touch Elastography (STE), using Liver Biopsy (LB) as 'Gold Standard'.

METHOD

152 consecutive subjects underwent a liver ViTE, VCTE, SWE and STE examination. A Receiver Operator Characteristic (ROC) analysis was performed on the measured stiffness values of each method. An inter- intra-observer analysis was also performed.

RESULTS

The ViTE, VCTE, SWE and STE ROC analysis resulted in an AUC of 0.9481, 0.9900, 0.9621 and 0.9683 for F ≥ F1, 0.9698, 0.9767, 0.9931 and 0.9834 for F ≥ F2, 0.9846, 0.9651, 0.9835 and 0.9763 for F ≥ F3, and 0.9524, 0.9645, 0.9656, and 0.9509 for F = F4, respectively. ICC scores were 0.98 for Inter-observer and 0.97 for Intra-observer variability analysis.

CONCLUSION

ViTE performance in CLD stage differentiation is comparable to the performance of VCTE, SWE and STE.

摘要

目的

慢性肝病（CLD）被认为是主要死因之一。超声弹性成像（USE）是一种CLD评估成像方法。本研究旨在评估最近推出的一种USE商业替代方法——视觉瞬态弹性成像（ViTE），并将其与三种已确立的USE方法，即振动控制瞬态弹性成像（VCTE）、剪切波弹性成像（SWE）和声学触诊弹性成像（STE）进行比较，以肝活检（LB）作为“金标准”。

方法

152名连续受试者接受了肝脏ViTE、VCTE、SWE和STE检查。对每种方法测得的硬度值进行了受试者工作特征（ROC）分析。还进行了观察者间和观察者内分析。

结果

对于F≥F1，ViTE、VCTE、SWE和STE的ROC分析得出的曲线下面积（AUC）分别为0.9481、0.9900、0.9621和0.9683；对于F≥F2，分别为0.9698, 0.9767, 0.9931和0.9834；对于F≥F3，分别为0.9846, 0.9651, 0.9835和0.9763；对于F = F4，分别为0.9524, 0.9645, 0.9656和0.9509。观察者间分析的组内相关系数（ICC）分数为0.98，观察者内变异性分析的ICC分数为0.97。