Soundarya B, Massillamani F, Kailasam S, Jayashree G, Narmadha N, Sornaa N
Department of Oral Medicine and Radiology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
J Midlife Health. 2022 Apr-Jun;13(2):157-162. doi: 10.4103/jmh.jmh_61_21. Epub 2022 Sep 16.
The aim of our study was to evaluate salivary estradiol and salivary calcium in postmenopausal women with varying degrees of oral dryness. The primary objective was to establish the interrelationship between salivary parameters and oral health status among menopausal women and compare the same with premenopausal women and normal controls.
The study included 60 women Group I consisted of healthy menstruating women between 25 and 34 years of age. In Group II premenopausal women between 35 and 45 years of age were present and Group III consisted of menopausal women between 45 and 60 years of age. Unstimulated saliva was collected from the participants and estradiol analysis was done using ELISA method and calcium analysis was done using Arsenazo III reaction using colorimetric method. The oral health status in these patients was determined by using xerostomia score, Russell's periodontal score, and oral hygiene index. The values obtained were subjected to statistical analysis and the results were derived.
On oral examination, most of them had poor oral hygiene, periodontal disease, and moderate to severe levels of xerostomia. Salivary estradiol levels were low and salivary calcium levels were high among postmenopausal women and as salivary estradiol levels decreased there was an increase in xerostomia scores and salivary calcium. And also as salivary calcium levels increased the periodontal disease scores increased. All parameters were within normal limits among healthy menstruating women.
Saliva can be a preferred medium and an emerging alternative for serum to estimate estradiol and calcium levels. As a dentist, we have to educate them about the oral changes they will experience during menopause and emphasize its strong association between low estradiol levels. Oral hygiene instructions should be given for the maintenance of healthy periodontium. Menopausal women who experience severe postmenopausal symptoms can be identified and the dentist and gynecologist can work hand in hand to treat the symptoms of these women.
本研究旨在评估不同程度口腔干燥的绝经后女性的唾液雌二醇和唾液钙水平。主要目的是确定绝经后女性唾液参数与口腔健康状况之间的相互关系,并将其与绝经前女性和正常对照组进行比较。
本研究纳入60名女性。第一组为25至34岁的健康育龄女性。第二组为35至45岁的绝经前女性,第三组为45至60岁的绝经后女性。收集参与者的非刺激性唾液,采用酶联免疫吸附测定法(ELISA)进行雌二醇分析,采用偶氮胂III反应比色法进行钙分析。通过口干评分、罗素牙周评分和口腔卫生指数来确定这些患者的口腔健康状况。对获得的值进行统计分析并得出结果。
口腔检查发现,大多数患者口腔卫生差、患有牙周疾病且口干程度为中度至重度。绝经后女性的唾液雌二醇水平较低,唾液钙水平较高,随着唾液雌二醇水平降低,口干评分和唾液钙水平升高。此外随着唾液钙水平升高,牙周疾病评分也升高。所有参数在健康育龄女性中均在正常范围内。
唾液可作为一种首选介质,是用于估计雌二醇和钙水平的血清的新兴替代物。作为牙医,我们必须向她们告知绝经期间会经历的口腔变化,并强调其与低雌二醇水平的密切关联。应给予口腔卫生指导以维持健康的牙周组织。可以识别出经历严重绝经后症状的绝经后女性,牙医和妇科医生可以携手治疗这些女性的症状。