Del'Aguila-Silva Priscila, Dos Santos Fabiana Cirino, Dos Santos Victor José Correia, Uscategui Ricardo Andres Ramirez, Padilha-Nakaghi Luciana Cristina, Mariano Renata Sitta Gomes, Rodriguez Mariana Garcia Kako, Amoroso Lizandra, Vicente Wilter Ricardo Russiano, Feliciano Marcus Antônio Rossi
Departamento de Patologia, Reprodução e Saúde Única, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista "Júlio de Mesquita Filho", Jaboticabal, SP, Brasil.
Grupo de investigación INCA-CES, Facultad de Medicina Veterinaria y Zootecnia, Universidad CES, Medellín, Colombia.
Anim Reprod. 2022 Oct 10;19(3):e20220014. doi: 10.1590/1984-3143-AR2022-0014. eCollection 2022.
The objective was to evaluate the blood flow of the uterine artery (UA) and umbilical artery (UMB) in the physiological pregnancy of goats by means of Doppler throughout the gestational period. Twenty-five Saanen goats weighing 55 ± 10 kg and aged between 2 and 5 were evaluated weekly, from the 21 until the 143 day of gestation, and daily from that period until parturition. Values for peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance (RI) and pulsatility (PI) indices of the uterine and umbilical arteries were determined. The values obtained were correlated with gestational age by Spearman's test, tested for adjustment to regression models and compared with the number of fetuses by ANOVA. The umbilical cord was first visualized at 28 days. Of the variables evaluated, RIUMB and PIUMB correlated with gestational age (p<0.001; and 0.046; respectively) and RIUMB had a low negative correlation with the number of fetuses per pregnancy (p = 0.003; r- Spearman = - 0.218). PSVUMB and EDVUMB values did not correlate with gestational age (p=0.737 and 0.768, respectively), but there was a decrease in the mean values throughout pregnancy (PSVUMB= 0.07; 0.31 and EDVUMB= 0.01; 0.06) as well as the change in the flow pattern of the spectral trace. The mean values of the uterine artery dopplervelocimetric variables PSVUT, EDVUT, PIUT and RIUT did not correlate with gestational age (p= 0.324; 0.372, 0.143; 0.13; respectively). It is expected that the results obtained will contribute to a broader understanding of the hemodynamic changes resulting from pregnancy in goats.
目的是通过多普勒超声评估山羊生理妊娠期间子宫动脉（UA）和脐动脉（UMB）的血流情况，贯穿整个妊娠期。对25只体重55±10千克、年龄在2至5岁之间的萨能山羊进行评估，从妊娠第21天至143天每周评估一次，从该时期直至分娩每天评估一次。测定子宫和脐动脉的收缩期峰值流速（PSV）、舒张末期流速（EDV）以及阻力指数（RI）和搏动指数（PI）。通过Spearman检验将获得的值与胎龄进行相关性分析，检验其对回归模型的拟合情况，并通过方差分析与胎儿数量进行比较。脐带在第28天首次可见。在所评估的变量中，脐动脉阻力指数（RIUMB）和搏动指数（PIUMB）与胎龄相关（分别为p<0.001和0.046），并且RIUMB与每次妊娠的胎儿数量呈低负相关（p = 0.003；Spearman相关系数r = - 0.218）。脐动脉收缩期峰值流速（PSVUMB）和舒张末期流速（EDVUMB）值与胎龄不相关（分别为p = 0.737和0.768），但在整个妊娠期间平均值下降（PSVUMB = 0.07；0.31，EDVUMB = 0.01；0.06），同时频谱轨迹的血流模式也发生变化。子宫动脉多普勒流速测定变量PSVUT、EDVUT、PIUT和RIUT的平均值与胎龄不相关（分别为p = 0.324；0.372，0.143；0.13）。预期所获得的结果将有助于更广泛地了解山羊妊娠引起的血流动力学变化。
