Beltrame Renato Travassos, Covre Carolina, Littig Lucas Buss, Martins Amanda de Barros, Quirino Celia Raquel, Junior Aylton Bartholazzi, da Costa Ricardo Lopes Dias
Centro Universitário do Espírito Santo (UNESC), Avenida Fioravante Rossi, 2930, Colatina, ES, 29703-900, Brazil.
Centro Universitário do Espírito Santo (UNESC), Avenida Fioravante Rossi, 2930, Colatina, ES, 29703-900, Brazil.
Theriogenology. 2017 Mar 15;91:55-61. doi: 10.1016/j.theriogenology.2016.12.026. Epub 2016 Dec 27.
In sheep, there is a lack of information on the behaviour of hemodynamic indices and parameters of blood flow velocity of the uterine artery during pregnancy, making it impossible to determine the real meaning of the values found and their probable relevance in normal physiological or pathological states. The objective of the present study was to evaluate the blood flow velocity parameters and hemodynamic indices of the uterine artery in ewes (18) during pregnancy (33). Based on non-invasive colour Doppler sonography, we evaluated the peak systolic velocity (PS), end diastolic velocity (ED), time-averaged maximum and minimum velocity in a cardiac cycle (TAMAX and TAMEAN), pulsatility index (PI), resistance index (RI), systolic/diastolic ratio (S/D), heart rate (HR), arterial diameter (AD) and the blood flow volume (BFV). Examinations started on day 28 and continued at two-week intervals until parturition. The Doppler parameters and the diameter of the uterine artery underwent significant changes during pregnancy. In the evaluated animals, indices related to resistance of the uterine artery, namely the impedance of blood flow, decreased throughout the initial, middle and late stages of gestation (PI: 1.15, 1.04, 0.97; RI: 0.61, 0.59, 0.57; S/D: 2.68, 2.52, 2.39, respectively) (p < 0.05). In contrast, the contents related to higher uterine irrigation increased during gestation (PS, ED, TAMAX, TAMEAN, HR, AD and BFV) (p < 0.05). No differences were found between the means of the variables in relation to the right and left uterine arteries and between single and multiple pregnancies in the hemodynamic indices. The present study is the first to demonstrate changes in uterine hemodynamics throughout pregnancy in sheep.
在绵羊中，关于妊娠期间子宫动脉血流动力学指标和血流速度参数的行为缺乏相关信息，因此无法确定所发现数值的实际意义及其在正常生理或病理状态下可能的相关性。本研究的目的是评估妊娠期间（33周）18只母羊子宫动脉的血流速度参数和血流动力学指标。基于非侵入性彩色多普勒超声，我们评估了收缩期峰值速度（PS）、舒张末期速度（ED）、心动周期中的时间平均最大和最小速度（TAMAX和TAMEAN）、搏动指数（PI）、阻力指数（RI）、收缩/舒张比（S/D）、心率（HR）、动脉直径（AD）和血流量（BFV）。检查从第28天开始，每隔两周进行一次，直至分娩。妊娠期间，子宫动脉的多普勒参数和直径发生了显著变化。在所评估的动物中，与子宫动脉阻力相关的指标，即血流阻抗，在妊娠的早期、中期和晚期均有所下降（PI分别为1.15、1.04、0.97；RI分别为0.61、0.59、0.57；S/D分别为2.68、2.52、2.39）（p < 0.05）。相反，与子宫较高灌注相关的指标在妊娠期间有所增加（PS、ED、TAMAX、TAMEAN、HR、AD和BFV）（p < 0.05）。在血流动力学指标方面，左右子宫动脉变量的均值之间以及单胎和多胎妊娠之间均未发现差异。本研究首次证明了绵羊妊娠全过程中子宫血流动力学的变化。
