Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2022 Oct 6;13:1001316. doi: 10.3389/fendo.2022.1001316. eCollection 2022.
A circadian rhythm is an internalized timing system that synchronizes the cellular, behavioral, and physiological processes of organisms to the Earth's rotation. Because all physiological activities occur at a specific time, circadian rhythm disturbances can lead to various pathological disorders and diseases. Growing evidence has shown that the circadian clock is tightly connected to male fertility, and circadian perturbations contribute to infertility. The night shiftwork, insufficient sleep, and poor sleep quality are common causes of circadian disturbances, and many studies have reported that they impair sperm quality and increase the risk of male infertility. However, research on the impacts of light, body temperature, and circadian/circannual rhythms is relatively lacking, although some correlations have been demonstrated. Moreover, as the index of sperm quality was diverse and study designs were non-uniform, the conclusions were temporarily inconsistent and underlying mechanisms remain unclear. A better understanding of whether and how circadian disturbances regulate male fertility will be meaningful, as more scientific work schedules and rational lifestyles might help improve infertility.
昼夜节律是一种内在的时间系统，它使生物体的细胞、行为和生理过程与地球的自转同步。由于所有生理活动都发生在特定的时间，因此昼夜节律紊乱会导致各种病理紊乱和疾病。越来越多的证据表明，生物钟与男性生育力紧密相连，昼夜节律紊乱会导致不育。轮班工作、睡眠不足和睡眠质量差是昼夜节律紊乱的常见原因，许多研究报告称，它们会损害精子质量，增加男性不育的风险。然而，关于光、体温和昼夜/年节律的影响的研究相对较少，尽管已经证明了一些相关性。此外，由于精子质量的指标多种多样，研究设计也不一致，因此结论暂时不一致，潜在机制尚不清楚。更好地了解昼夜节律紊乱是否以及如何调节男性生育力将是有意义的，因为更科学的工作时间表和合理的生活方式可能有助于改善不育。
