Kong Yiya, Yu Xiaobin, Peng Gang, Wang Fang, Yin Yajun
Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
J Funct Biomater. 2022 Oct 1;13(4):172. doi: 10.3390/jfb13040172.
This study reports new phenomena of the interstitial fluid (ISF) microflow along perivascular and adventitial clearances (PAC) around neurovascular bundles. The fluorescent tracing was used to observe the ISF flow along the PAC of neurovascular bundles in 8-10 week old BALB/c mice. The new results include: (1) the topologic structure of the PAC around the neurovascular bundles is revealed; (2) the heart-orientated ISF flow along the PAC is observed; (3) the double-belt ISF flow along the venous adventitial clearance of the PAC is recorded; (4) the waterfall-like ISF flow induced by the small branching vessel or torn fascia along the PAC is discovered. Based on the above new phenomena, this paper approached the following objectives: (1) the kinematic laws of the ISF flow along the PAC around neurovascular bundles are set up; (2) the applicability of the hypothesis on the PAC and its subspaces by numerical simulations are examined. The findings of this paper not only enriched the image of the ISF flow through the body but also explained the kernel structure of the ISF flow (i.e., the PAC). It helps to lay the foundation for the kinematics and dynamics of the ISF flow along the PAC around neurovascular bundles.
本研究报告了沿神经血管束周围血管周围和外膜间隙（PAC）的组织液（ISF）微流的新现象。采用荧光示踪法观察8-10周龄BALB/c小鼠神经血管束沿PAC的ISF流动。新结果包括：（1）揭示了神经血管束周围PAC的拓扑结构；（2）观察到沿PAC的向心性ISF流动；（3）记录了沿PAC静脉外膜间隙的双带ISF流动；（4）发现了沿PAC的小分支血管或撕裂筋膜诱导的瀑布样ISF流动。基于上述新现象，本文探讨了以下目标：（1）建立沿神经血管束周围PAC的ISF流动的运动学规律；（2）通过数值模拟检验PAC及其子空间假设的适用性。本文的研究结果不仅丰富了ISF在体内流动的图像，还解释了ISF流动的核心结构（即PAC）。它有助于为沿神经血管束周围PAC的ISF流动的运动学和动力学奠定基础。
