Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Trends Neurosci. 2020 Jul;43(7):458-466. doi: 10.1016/j.tins.2020.04.003. Epub 2020 May 15.
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic-lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.
近年来，神经胶质淋巴假说以及脑膜淋巴管的发现，突出了液体在中枢神经系统（CNS）内的定向运输。成像研究以及对液体运输的操作表明，神经胶质-淋巴管系统在清除淀粉样β和其他蛋白质方面起着关键作用。因此，神经胶质-淋巴管系统是治疗神经退行性疾病的新靶点。不出所料，大脑中新的管道系统的引入引起了争议。本文将重点介绍我们对大脑液体运输系统的了解，包括实验数据不足和仍有争议的方面。
