Alfvén G, Bergqvist G, Bolme P, Eriksson M
Acta Paediatr Scand. 1978 Nov;67(6):769-73. doi: 10.1111/j.1651-2227.1978.tb16259.x.
The longterm prognosis of neonatal septicemia during the first four weeks of life has been estimated. Of 90 infants with the diagnosis of neonatal septicemia during a five-year period, 1969--1973, 65 infants survived the initial treatment. Another two infants died with complications of their main disease, intestinal atresia, at the age of two months. Thus the total mortality in neonatal septicemia in this series was 30%. The remaining 63 children have been investigated between ages of 2 1/2 and 6 1/2 years. Of these 63 children we have found 14 children (22% of the surviving) with handicaps where the septicemia can be regarded as a possible cause of the handicap. Of these 14 children only six had an "uncomplicated" septicemia while four of them had meningitis and four had osteomyelitis. Furthermore, of the 14 handicapped children nine were delivered preterm (28--36 weeks) and all of them had one or more additional neonatal diagnoses than septicemia. The prognosis, both immediate and longterm, of neonatal septicemia in the present series compares favourably to most international studies. The importance of early detection together with an aggresive treatment of the septicemia is stressed and is considered as the main reason for the good prognosis.
已对出生后前四周新生儿败血症的长期预后进行了评估。在1969年至1973年的五年期间，90名被诊断为新生儿败血症的婴儿中，65名婴儿在初始治疗后存活。另外两名婴儿在两个月大时死于主要疾病——肠道闭锁的并发症。因此，该系列新生儿败血症的总死亡率为30%。其余63名儿童在2岁半至6岁半之间接受了调查。在这63名儿童中，我们发现14名儿童（占存活者的22%）存在缺陷，败血症可被视为这些缺陷的可能原因。在这14名儿童中，只有6名患有“无并发症”的败血症，其中4名患有脑膜炎，4名患有骨髓炎。此外，在这14名有缺陷的儿童中，9名是早产儿（28至36周），并且他们所有人除败血症外还有一种或多种其他新生儿诊断。本系列中新生儿败血症的近期和长期预后与大多数国际研究相比都比较良好。强调了早期发现以及积极治疗败血症的重要性，并认为这是预后良好的主要原因。
