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新生儿败血症发病率上升:致病微生物及易感风险因素

Increasing incidence of neonatal septicemia: causative organism and predisposing risk factors.

作者信息

Bennet R, Eriksson M, Zetterström R

出版信息

Acta Paediatr Scand. 1981 Mar;70(2):207-10. doi: 10.1111/j.1651-2227.1981.tb05543.x.

DOI:10.1111/j.1651-2227.1981.tb05543.x
PMID:7234404
Abstract

The incidence of neonatal septicemia in the referral area of St. Göran's Children's Hospital in Stockholm has been studied during a ten-year period (1969-1978). An increase was noticed during the period 1974-1978 in comparison with the preceding five-year period. The incidence per 1 000 live births was 1.4 and 3.1, respectively. The incidence of osteoarthritis increased from 0.21 to 0.41 per 1 000. Mortality rate from neonatal septicemia remained unchanged. Gram-negative organisms as an etiologic factor seemed to be decreasing while staphylococcal infections have increased. Group B streptococcal infection occurred with the same frequency during the whole period. The low incidence of enteric organisms might be related to the common practice of feeding the babies with milk from their own mothers. Perinatal risk factors were equally common in both five-year periods. The observed increase of the prevalence of neonatal septicemia caused by Staphylococcus aureus may be explained by a higher rate of survival of highly susceptible low-birthweight infants and other sick neonates treated in the neonatal intensive care unit.

摘要

对斯德哥尔摩圣戈兰儿童医院转诊区域内新生儿败血症的发病率进行了为期十年(1969 - 1978年)的研究。与前一个五年期相比,1974 - 1978年期间发病率有所上升。每1000例活产儿的发病率分别为1.4和3.1。骨关节炎的发病率从每1000例0.21升至0.41。新生儿败血症的死亡率保持不变。革兰氏阴性菌作为病因似乎在减少,而葡萄球菌感染有所增加。B组链球菌感染在整个期间的发生频率相同。肠道菌的低发病率可能与用母乳喂哺婴儿的普遍做法有关。围产期危险因素在两个五年期内同样常见。观察到的由金黄色葡萄球菌引起的新生儿败血症患病率上升,可能是由于在新生儿重症监护病房接受治疗的高度易感低体重婴儿和其他患病新生儿的存活率提高所致。

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