Holt Sylvester, Arrey Gerard, Regenberg Birgitte
Department of Biology, University of Copenhagen, Copenhagen DK-2100, Denmark.
Department of Biology, University of Copenhagen, Copenhagen DK-2100, Denmark.
Trends Biochem Sci. 2023 Apr;48(4):317-320. doi: 10.1016/j.tibs.2022.09.010. Epub 2022 Oct 21.
Extrachromosomal circular DNA (eccDNA) can shape the genomes of somatic cells, but how it impacts genomes across generations is largely unexplored. We propose that genomes can rearrange via circular intermediates across generations and show that up to 6% of a mammalian genome can have changed gene order through eccDNA.
染色体外环状DNA（eccDNA）能够塑造体细胞的基因组，但它如何在世代间影响基因组在很大程度上尚未得到探索。我们提出，基因组可以通过环状中间体在世代间发生重排，并表明高达6%的哺乳动物基因组可通过eccDNA改变基因顺序。
