Kramer M R, van Dijk J M, Hadas I, Hershko C
Postgrad Med J. 1986 Nov;62(733):1037-41. doi: 10.1136/pgmj.62.733.1037.
We describe a patient with primary amyloidosis in whom multiple osteolytic lesions caused by amyloid bone tumours developed, and review the clinical features of the 18 cases with primary amyloidosis in whom destructive bone lesions have been reported. In contrast to amyloidosis associated with multiple myeloma, destructive lesions in the primary disease are mainly located to long bones; joint involvement is common, and radionuclide bone scan shows pronounced uptake of 99mTc-PP by the destructive bone lesions. Despite the superficial similarity between the destructive bone lesions associated with primary amyloidosis and multiple myeloma, distinction between these entities on clinical grounds is possible and may be easily confirmed by direct aspiration of the osteolytic infiltrates.
我们描述了一名原发性淀粉样变性患者，该患者出现了由淀粉样骨肿瘤引起的多处溶骨性病变，并回顾了18例已报道有破坏性骨病变的原发性淀粉样变性患者的临床特征。与多发性骨髓瘤相关的淀粉样变性不同，原发性疾病中的破坏性病变主要位于长骨；关节受累很常见，放射性核素骨扫描显示破坏性骨病变对99mTc-PP有明显摄取。尽管原发性淀粉样变性相关的破坏性骨病变与多发性骨髓瘤在表面上有相似之处，但基于临床理由区分这两种疾病是可能的，并且通过对溶骨性浸润进行直接抽吸可以很容易地得到证实。
