DiRaimondo C R, Casey T T, DiRaimondo C V, Stone W J
Nephron. 1986;43(1):22-7. doi: 10.1159/000183712.
Amyloid bone lesions were found in 2 chronic hemodialysis patients presenting with pathologic hip fractures. These amyloid deposits were noted as lytic defects on plain skeletal radiographs. No evidence for disseminated amyloidosis was discovered on physical examination, skin biopsy, or bone marrow biopsy. Myeloma, other plasma cell dyscrasia, and preceding chronic inflammatory states were not found in either patient. The amyloid deposits had staining characteristics suggestive of secondary amyloid based on the potassium permanganate reaction. Isolated amyloid bone deposits should be included in the differential diagnosis of lytic bone lesions or pathologic fractures in chronic dialysis patients.
在2例出现病理性髋部骨折的慢性血液透析患者中发现了淀粉样骨病变。这些淀粉样沉积物在普通骨骼X线片上表现为溶骨性缺损。体格检查、皮肤活检或骨髓活检均未发现播散性淀粉样变的证据。两名患者均未发现骨髓瘤、其他浆细胞异常增生或先前的慢性炎症状态。根据高锰酸钾反应，淀粉样沉积物的染色特征提示为继发性淀粉样变。孤立性淀粉样骨沉积物应纳入慢性透析患者溶骨性骨病变或病理性骨折的鉴别诊断。
