Kimura Tomohiro, Wakabayashi Masakazu, Kobori Shuichi, Aoki Kana, Yoshida Hayato, Minoshima Kou, Doumoto Yoshinori, Hosaka Miki, Ushiku Hideki, Aisaki Kazuo, Funatsu Kentarou
Dept. of Surgery, Sagamihara Kyodo Hospital.
Gan To Kagaku Ryoho. 2022 Oct;49(10):1121-1124.
Respiratory symptoms are rarely reported as side effects of oxaliplatin, 5-fluorouracil, and Leucovorin(FOLFOX)therapy. We report a case of a patient with FOLFOX-induced unilateral interstitial pneumonia. The patient was a 68-year-old man who underwent ileocecal resection of cecum cancer. FOLFOX regimen was started as an adjuvant chemotherapy. After the administration of 11 courses, he visited our hospital with fever, dyspnea, and anorexia. We diagnosed this as FOLFOX- induced unilateral interstitial pneumonia through a blood test, chest radiograph, computed tomography, and bronchoscopy. Treatment was started with 30 mg of prednisolone, and the dosage was gradually decreased. The patient responded well to the treatment and was discharged from the hospital without any complications on the 33th day after admission.
呼吸系统症状很少被报告为奥沙利铂、5-氟尿嘧啶和亚叶酸（FOLFOX）疗法的副作用。我们报告一例FOLFOX诱导的单侧间质性肺炎患者。该患者为一名68岁男性，因盲肠癌接受了回盲部切除术。开始使用FOLFOX方案作为辅助化疗。在给予11个疗程后，他因发热、呼吸困难和厌食前来我院就诊。我们通过血液检查、胸部X光片、计算机断层扫描和支气管镜检查诊断为FOLFOX诱导的单侧间质性肺炎。开始使用30毫克泼尼松龙进行治疗，剂量逐渐减少。患者对治疗反应良好，入院后第33天无任何并发症出院。
