2,5 -己二酮对肉芽组织中新形成胶原蛋白的影响。

The effect of 2,5-hexanedione on newly formed collagen in granulation tissue.

作者信息

Braendgaard H, Jørgensen P H, Andreassen T T

出版信息

Pharmacol Toxicol. 1987 Jul;61(1):63-5. doi: 10.1111/j.1600-0773.1987.tb01774.x.

DOI:10.1111/j.1600-0773.1987.tb01774.x

Abstract

The mechanical strength of newly formed collagen in granulation tissue was investigated by implantation of cellulose sponges into rats intoxicated with 2,5-hexanedione (2,5-HD) and control rats. Intoxication with 2,5-HD caused a significant decrease in mechanical strength after 20 days of implantation. No differences were found between 2,5-HD intoxicated and control groups in the amount of collagen formed in the sponges. The mechanical strength of granulation tissue depends on formation and cross-linking of the newly formed collagen fibrils. 2,5-HD is known to react with epsilon-amino groups of lysine and it is therefore able to interfere with both fibril aggregation and cross-linking of the collagen. On the other hand, 2,5-HD induces the formation of cross-links in intact tendon collagen. Therefore, we stress that it is essential to distinguish between intact and newly formed fibrils when evaluating the effect of 2,5-HD on fibillary proteins.

摘要

通过将纤维素海绵植入用2,5 -己二酮（2,5 - HD）中毒的大鼠和对照大鼠体内，研究了肉芽组织中新形成胶原蛋白的机械强度。植入20天后，2,5 - HD中毒导致机械强度显著降低。在海绵中形成的胶原蛋白量方面，2,5 - HD中毒组和对照组之间未发现差异。肉芽组织的机械强度取决于新形成的胶原纤维的形成和交联。已知2,5 - HD与赖氨酸的ε-氨基反应，因此它能够干扰胶原纤维的聚集和交联。另一方面，2,5 - HD诱导完整肌腱胶原蛋白中交联的形成。因此，我们强调在评估2,5 - HD对纤维状蛋白质的影响时，区分完整的和新形成的纤维至关重要。