Department of Pharmacology, Bahauddin Zakariya University, Multan, Pakistan.
Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
Drug Dev Ind Pharm. 2022 Oct;48(10):566-574. doi: 10.1080/03639045.2022.2140352. Epub 2022 Nov 1.
Murraya koenigii (Mk) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The excessive use of cisplatin (Cis> 50 mg/m) is associated with nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, and allergic reactions. Remedial measures are needed for the protection of nephrotoxicity against cisplatin. Thus, we have investigated Mk leaf extract's nephroprotective effects to prevent cisplatin-induced nephrotoxicity in Wistar albino rats. The presence of polyphenols, phenolic compounds, tannins, and saponins was revealed during phytochemical investigation, and antioxidant activity was recorded. There were no toxicological symptoms in the treated rats, and no anatomical, physiological, or histological abnormalities were found compared to the control rats. The results of correcting cisplatin-induced nephrotoxicity revealed that the extract has a significant ability to treat kidney damage, with most parameters returning to normal after only three weeks of therapy. It was concluded that co-administered cisplatin with Mk leaves extract showed exceptional nephroprotective effects at a 400 mg/kg dose ratein Cis-induced nephrotoxicity.
九里香（Mk）是一种古老的植物，在非洲、亚洲和拉丁美洲都具有重要的治疗价值。顺铂（Cis>50mg/m）的过度使用与肾毒性、耳毒性、胃肠道毒性、骨髓抑制和过敏反应有关。需要采取补救措施来保护顺铂引起的肾毒性。因此，我们研究了九里香叶提取物的肾保护作用，以预防 Wistar 白化大鼠的顺铂诱导的肾毒性。在植物化学研究中发现了多酚、酚类化合物、单宁和皂苷的存在，并记录了抗氧化活性。与对照组大鼠相比，治疗组大鼠没有出现毒理学症状，也没有发现解剖、生理或组织学异常。纠正顺铂诱导的肾毒性的结果表明，该提取物具有显著的治疗肾脏损伤的能力，仅经过三周的治疗，大多数参数就恢复正常。研究得出结论，在 400mg/kg 剂量率下，顺铂与九里香叶提取物联合使用在 Cis 诱导的肾毒性中表现出了卓越的肾保护作用。
