Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, China.
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Bioengineered. 2021 Dec;12(2):12702-12721. doi: 10.1080/21655979.2021.2009977.
The overuse of cisplatin (>50 mg/m) is limited to nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, and allergic reactions. The objective of this study was to investigate the nephroprotective effects of and extracts on cisplatin-induced nephrotoxicity in Wistar albino rats. The study involved male Wistar albino rats of 8 weeks weighing 220-270 g. A single injection of 5 mg/kg was injected into the rats for nephrotoxicity. Rats were divided into four groups based on dose conentrations. Blood and urine samples of rats were collected on the 0, 7, 14, and 21 days for nephrological analysis. The results showed that Cis + DC/Cis + EP (600 mg/kg) significantly (p < 0.001) increased the body weight and reduced the kidney weight of cisplatin-induced nephrotoxicity in rats (p < 0.001) as compared to Cis group. The results showed that 600 mg/kg administration of Cis + DC/Cis +EP successfully (p < 0.005) improved the urine and plasmin creatinine, Na, and K level compared to the Cis group. Histopathological results confirmed that Cis + EP/Cis + DC effectively improved the renal abnormalities. It is concluded that the co-administration of Cis + EP extract showed exceptional nephroprotective effects at a dose rate of 600 mg/kg.
顺铂（>50mg/m）的过度使用受到肾毒性、耳毒性、胃肠道毒性、骨髓抑制和过敏反应的限制。本研究的目的是研究 和 提取物对顺铂诱导的 Wistar 白化大鼠肾毒性的肾保护作用。该研究涉及 8 周龄、体重 220-270g 的雄性 Wistar 白化大鼠。对大鼠进行单次注射 5mg/kg 以诱导肾毒性。根据剂量浓度将大鼠分为四组。在第 0、7、14 和 21 天收集大鼠的血液和尿液样本进行肾脏分析。结果表明，与 Cis 组相比， Cis + DC/Cis + EP（600mg/kg）显著（p<0.001）增加了顺铂诱导的肾毒性大鼠的体重并降低了肾脏重量（p<0.001）。结果表明，与 Cis 组相比，600mg/kg 剂量的 Cis + DC/Cis + EP 成功（p<0.005）改善了尿液和血浆肌酐、Na 和 K 水平。组织病理学结果证实 Cis + EP/Cis + DC 有效改善了肾脏异常。综上所述，Cis + EP 提取物的联合给药在 600mg/kg 的剂量率下显示出出色的肾保护作用。
