Indiana University School of Medicine, Indianapolis, IN.
Glick Eye Institute. Department of Ophthalmology, Indiana University, Indianapolis, IN.
Mol Vis. 2022 Aug 19;28:220-229. eCollection 2022.
The goal was to evaluate optical coherence tomography angiography (OCT-A) as a biomarker to correlate retinal vessel density (VD) with diabetic retinopathy (DR) severity and visual acuity, as well as track antivascular endothelial growth factor (VEGF) treatment efficacy.
This retrospective cohort study analyzed the automatically quantified VDs of the superficial vascular complex (SVC) and deep vascular complex (DVC), including the whole, foveal, and parafoveal VDs, on quality OCT-A scans in patients diagnosed with DR. A multivariate linear regression and analysis of variance (ANOVA) analysis compared VDs to DR severity, visual acuity, and demographic factors. A linear mixed analysis determined the effects of VD by whether anti-VEGF therapy was given to patients with OCT-A scans at multiple time points.
There was a positive correlation of the VDs in both the SVC whole and parafoveal VD and DVC parafoveal VD with decreased DR severity and increased visual acuity (p≤0.001). The DVC whole VD was also positively correlated with increased visual acuity (p<0.001). There was no difference in the VDs associated with anti-VEGF treatment over time.
OCT-A VD shows promise for diagnosing and monitoring DR using DR severity and visual acuity. Anti-VEGF treatment had no significant effect (p=0.063) on vascular density in diabetic retinopathy.
评估光相干断层扫描血管造影术（OCT-A）作为一种生物标志物，以评估视网膜血管密度（VD）与糖尿病视网膜病变（DR）严重程度和视力的相关性，并追踪抗血管内皮生长因子（VEGF）治疗的疗效。
本回顾性队列研究分析了在诊断为 DR 的患者的高质量 OCT-A 扫描中自动量化的浅层血管复合体（SVC）和深层血管复合体（DVC）的 VD，包括整体、中心凹和旁中心凹 VD。多元线性回归和方差分析（ANOVA）分析比较了 VD 与 DR 严重程度、视力和人口统计学因素。线性混合分析确定了在 OCT-A 扫描的多个时间点是否给予抗 VEGF 治疗对 VD 的影响。
SVC 整体和旁中心凹 VD 以及 DVC 旁中心凹 VD 的 VD 与 DR 严重程度降低和视力提高呈正相关（p≤0.001）。DVC 整体 VD 也与视力提高呈正相关（p<0.001）。随着时间的推移，抗 VEGF 治疗对 VD 没有显著影响（p=0.063）。
OCT-A VD 有望通过 DR 严重程度和视力来诊断和监测 DR。抗 VEGF 治疗对糖尿病视网膜病变的血管密度没有显著影响（p=0.063）。
