Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3492-3498. doi: 10.1167/iovs.19-26848.
To evaluate the effect of age on global and sectoral vascular parameters of the peripapillary area and macula in healthy eyes by using optical coherence tomography angiography (OCT-A).
This retrospective cross-sectional study included 239 eyes of 172 healthy subjects. Subjects were scanned using the high-definition disc angio scan (4.5 × 4.5 mm), retina angio scan (6 × 6 mm), and optic nerve head/ganglion cell complex (GCC) modes of OCT-A. Global and sectoral circumpapillary vessel density (VD), parafoveal VD, retinal nerve fiber layer (RNFL), and GCC thickness parameters were modeled in terms of age by using linear mixed-effect models incorporating covariates. Normalized slopes were calculated by dividing the absolute slopes by the mean value of the OCT-A parameters.
All global and sectoral circumpapillary VDs decreased significantly with increasing age, except for those in the temporal superior sector. The steepest slopes in the circumpapillary region were observed in nasal superior (-0.098%/y) and nasal inferior (-0.096%/y) sectors. The global, temporal, and superior macular VDs also decreased with increasing age, while the foveal, nasal, and inferior parameters did not. The temporal quadrant showed the steepest slope among the macular parameters (-0.068%/y). The RNFL and GCC thickness results showed similar trends.
Age substantially affected VD in most of the peripapillary and macular areas; however, the papillomacular bundle area did not show significant age-related vascular changes. These age-related global and sectoral differences in circumpapillary and macular VDs should be considered when assessing pathologic VD changes over time.
利用光相干断层扫描血管造影术（OCT-A）评估年龄对健康眼中视盘周围及黄斑区的整体及节段性血管参数的影响。
本回顾性横断面研究纳入了 172 例健康受试者的 239 只眼。使用高清盘状血管扫描（4.5×4.5mm）、视网膜血管扫描（6×6mm）和视神经头/节细胞复合体（GCC）模式对受试者进行 OCT-A 扫描。采用线性混合效应模型，结合协变量对各参数进行建模，评估年龄对全局和节段性视盘周围血管密度（VD）、旁中心凹 VD、视网膜神经纤维层（RNFL）和 GCC 厚度的影响。通过将绝对斜率除以 OCT-A 参数的平均值，计算出归一化斜率。
除颞上象限外，所有全局和节段性视盘周围 VD 均随年龄增长而显著降低。视盘周围区域的斜率最陡出现在鼻上（-0.098%/y）和鼻下（-0.096%/y）象限。随着年龄的增长，全局、颞侧和上侧黄斑 VD 也逐渐降低，而黄斑中心凹、鼻侧和下侧参数没有明显变化。黄斑参数中，颞侧象限的斜率最陡（-0.068%/y）。RNFL 和 GCC 厚度结果也呈现出相似的趋势。
年龄对大多数视盘周围和黄斑区域的 VD 有显著影响；然而，视盘黄斑束区域没有显示出与年龄相关的明显血管变化。在评估随时间推移病理性 VD 变化时，应考虑这些与年龄相关的视盘周围和黄斑 VD 的全局和节段性差异。
