Santos Francisco, Capela Ana Maria, Mateus Francisca, Nóbrega-Pereira Sandrina, Bernardes de Jesus Bruno
Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.
Comput Struct Biotechnol J. 2022 Oct 10;20:5652-5660. doi: 10.1016/j.csbj.2022.10.009. eCollection 2022.
Natural antisense transcripts (NATs) are coding or non-coding RNA sequences transcribed on the opposite direction from the same genomic locus. NATs are widely distributed throughout the human genome and seem to play crucial roles in physiological and pathological processes, through newly described and targeted mechanisms. NATs represent the intricate complexity of the genome organization and constitute another layer of potential targets in disease. Here, we focus on the interesting and unique role of non-coding NATs in cancer, paying particular attention to those acting as miRNA sponges.
天然反义转录本（NATs）是从同一基因组位点以相反方向转录的编码或非编码RNA序列。NATs广泛分布于整个人类基因组中，并且似乎通过新描述的靶向机制在生理和病理过程中发挥关键作用。NATs代表了基因组组织的复杂多样性，并构成了疾病中另一层潜在的靶点。在这里，我们聚焦于非编码NATs在癌症中有趣且独特的作用，尤其关注那些充当miRNA海绵的NATs。
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