Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, 381 Nanchen Road, Shanghai, 200444, China.
Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Cancer Hospital, Yunnan Cancer Center, Kunming, 650118, China.
Cell Oncol (Dordr). 2024 Feb;47(1):37-54. doi: 10.1007/s13402-023-00864-z. Epub 2023 Aug 29.
Lung cancer, being the most widespread and lethal form of cancer globally, has a high incidence and mortality rate primarily attributed to challenges associated with early detection, extensive metastasis, and frequent recurrence. In the context of lung cancer development, noncoding RNA molecules have a crucial role in governing gene expression and protein synthesis. Specifically, tRNA-derived fragments (tRFs), a subset of noncoding RNAs, exert significant biological influences on cancer progression, encompassing transcription and translation processes as well as epigenetic regulation. This article primarily examines the mechanisms by which tRFs modulate gene expression and contribute to tumorigenesis in lung cancer. Furthermore, we provide a comprehensive overview of the current bioinformatics analysis of tRFs in lung cancer, with the objective of offering a systematic and efficient approach for studying the expression profiling, functional enrichment, and molecular mechanisms of tRFs in this disease. Finally, we discuss the clinical significance and potential avenues for future research on tRFs in lung cancer. This paper presents a comprehensive systematic review of the existing research findings on tRFs in lung cancer, aiming to offer improved biomarkers and drug targets for clinical management of lung cancer.
肺癌是全球最普遍和致命的癌症形式，其发病率和死亡率高，主要归因于早期检测、广泛转移和频繁复发等方面的挑战。在肺癌发展的背景下，非编码 RNA 分子在调控基因表达和蛋白质合成方面发挥着关键作用。具体而言，tRNA 衍生的片段（tRFs）是一类非编码 RNA，对癌症的进展具有重要的生物学影响，包括转录和翻译过程以及表观遗传调控。本文主要探讨 tRFs 调节基因表达并促进肺癌发生的机制。此外，我们还全面概述了 tRFs 在肺癌中的当前生物信息学分析，旨在为研究 tRFs 在该疾病中的表达谱、功能富集和分子机制提供一种系统而有效的方法。最后，我们讨论了 tRFs 在肺癌中的临床意义和未来研究的潜在途径。本文对 tRFs 在肺癌中的现有研究结果进行了全面的系统综述，旨在为肺癌的临床管理提供改进的生物标志物和药物靶点。
