Basic Science Department, College of Nursing, University of Baghdad, Baghdad, Iraq.
Arch Razi Inst. 2022 Apr 30;77(2):703-707. doi: 10.22092/ARI.2022.356954.1945. eCollection 2022 Apr.
Obesity is one of the most important global health problems causing serious health risks and early death in human. It is also associated with disturbance of homeostasis of hormones and immunological biochemical factors inside the human body. This study aimed to evaluate the serum level of inhibin B and kisspeptin among Iraqi obese adult people and other biochemical parameters correlated with obesity. Inhibin B and levels of kisspeptin were evaluated in the samples of serum from 40 Iraqi obese adult patients and 30 healthy non-obese individuals. A significant decrease (<0.0001) was observed in the kisspeptin level in both males and females, compared to the control group. Moreover, inhibin B decreased significantly in obese females only (<0.001), while there was no differences between males and the control group in this regard. Finally, body mass index, serum glutamic pyruvic transaminase (SGPT), and leptin showed negative correlation with kisspeptin (0.01, 0.5, and 0.01), respectively. However, a positive association was observed with the level of Ca in the serum. On the other hand, inhibin B confirmed a positive correlation with SGPT. The present study revealed a significant increase in inhibin B and kisspeptin, with SGPT and Ca in the serum of obese patients, which could lead to complications and health problems among these patients.
肥胖是全球最重要的健康问题之一，会给人类健康带来严重风险，导致早亡。它还与人体内激素和免疫生化因子的内环境稳定紊乱有关。本研究旨在评估伊拉克肥胖成年人群的抑制素 B 和 kisspeptin 血清水平以及与肥胖相关的其他生化参数。评估了 40 名伊拉克肥胖成年患者和 30 名健康非肥胖个体的血清样本中的抑制素 B 和 kisspeptin 水平。与对照组相比，男性和女性的 kisspeptin 水平均显著下降(<0.0001)。此外，肥胖女性的抑制素 B 显著下降(<0.001)，而男性与对照组在这方面没有差异。最后，体重指数、血清谷氨酸丙酮酸转氨酶 (SGPT) 和瘦素与 kisspeptin 呈负相关(0.01、0.5 和 0.01)，而与血清中 Ca 呈正相关。另一方面，抑制素 B 与 SGPT 呈正相关。本研究表明，肥胖患者的血清中抑制素 B 和 kisspeptin 以及 SGPT 和 Ca 显著增加，这可能导致这些患者出现并发症和健康问题。
