Huie P E, Hatton D C, Muntzel M S, Metz J A, McCarron D A
Physiol Behav. 1987;40(4):425-9. doi: 10.1016/0031-9384(87)90026-6.
The interactive effects of psychosocial stress and diet on the development of hypertension were investigated in spontaneously hypertensive rats. Psychosocial stress, produced through manipulation of group housing conditions, was evaluated at three levels of dietary calcium and sodium: Low (0.1% Ca2+, 0.25% Na+), Intermediate (1.0% Ca2+, 0.45% Na+), and High (2.0% Ca2+, 1.0% Na+). After 13 weeks of exposure, stressed animals had higher blood pressure and lower serum ionized calcium than nonstressed animals across all diets. Likewise, animals on the low diet had higher blood pressures and lower ionized calcium values than animals on normal or high diets regardless of stress condition. The combination of stress and low diet produced the highest blood pressure and lowest serum ionized calcium values. The results suggest that stress both independently and in combination with dietary Ca2+ altered calcium metabolism. The interaction between psychosocial stress and dietary factors appears to contribute to reductions in serum ionized calcium and elevations in blood pressure in this experimental model of genetic hypertension.
在自发性高血压大鼠中研究了心理社会压力和饮食对高血压发展的交互作用。通过操纵群居条件产生心理社会压力，并在三种饮食钙和钠水平下进行评估：低水平（0.1% Ca2+，0.25% Na+）、中等水平（1.0% Ca2+，0.45% Na+）和高水平（2.0% Ca2+，1.0% Na+）。暴露13周后，在所有饮食条件下，应激动物的血压均高于非应激动物，血清离子钙水平低于非应激动物。同样，无论应激状态如何，低饮食组动物的血压均高于正常饮食组或高饮食组动物，且离子钙值更低。应激与低饮食的组合导致了最高的血压和最低的血清离子钙值。结果表明，应激单独作用以及与饮食Ca2+共同作用均会改变钙代谢。在这种遗传性高血压实验模型中，心理社会压力与饮食因素之间的相互作用似乎导致了血清离子钙降低和血压升高。
