Emerg Infect Dis. 2022 Nov;28(11):2270-2280. doi: 10.3201/eid2811.220577.
Since the COVID-19 pandemic began, different SARS-CoV-2 variants have been identified and associated with higher transmissibility than the ancestral nonvariant strain. During January 1, 2021-January 15, 2022, we assessed differences in clinical and viral parameters in a convenience sample of COVID-19 outpatients and inpatients 0-21 years of age in Columbus, Ohio, USA, according to the infecting variant, identified using a mutation-specific reverse transcription PCR assay. Of the 676 patients in the study, 17.75% were infected with nonvariant strains, 18.49% with the Alpha variant, 41.72% with Delta, and 16.42% with Omicron. Rates of SARS-COV-2/viral co-infections were 15.66%-29.41% and were comparable across infecting variants. Inpatients with acute Delta and Omicron infections had lower SARS-CoV-2 cycle threshold values and more frequent fever and respiratory symptoms than those with nonvariant strain infections. In addition, SARS-COV-2/viral co-infections and the presence of underlying conditions were independently associated with worse clinical outcomes, irrespective of the infecting variant.
自 COVID-19 大流行开始以来，已经确定了不同的 SARS-CoV-2 变体，它们的传染性高于原始非变体株。在 2021 年 1 月 1 日至 2022 年 1 月 15 日期间，我们根据在美国俄亥俄州哥伦布市的 COVID-19 门诊和住院患者的感染变体，使用突变特异性逆转录 PCR 检测评估了临床和病毒参数的差异。在这项研究的 676 名患者中，17.75%感染了非变体株，18.49%感染了 Alpha 变体，41.72%感染了 Delta 变体，16.42%感染了奥密克戎变体。SARS-CoV-2/病毒合并感染的发生率为 15.66%-29.41%，在不同的感染变体中具有可比性。急性 Delta 和奥密克戎感染的住院患者的 SARS-CoV-2 循环阈值较低，发热和呼吸道症状比感染非变体株的患者更为常见。此外，SARS-CoV-2/病毒合并感染和基础疾病的存在与更差的临床结局独立相关，而与感染变体无关。
