Keskin Mutlu, Kompuinen Jenna, Harmankaya İlknur, Karaçetin Didem, Nissilä Verneri, Gürsoy Mervi, Sorsa Timo, Gürsoy Ulvi Kahraman
Oral and Dental Health Department, Altınbaş University, 34147 Istanbul, Turkey.
Department of Periodontology, Institute of Dentistry, University of Turku, 20520 Turku, Finland.
Curr Issues Mol Biol. 2022 Sep 26;44(10):4439-4446. doi: 10.3390/cimb44100304.
Lactoferrin, an iron-binding glycoprotein, and calprotectin, a calcium binding protein, are sensitive markers of inflammation and their fecal levels increase during radiotherapy of prostate cancer patients. With this background, we analyzed mouthrinse calprotectin and lactoferrin levels of head- and neck-cancer patients before, during and after radiotherapy.
Twenty cancer patients (mean age 55.85 ± 15.01, 80% male), who had been planned to undergo radiotherapy to the head and neck area, were included in this study. Mouthrinse samples were collected before radiotherapy, at the 3rd and 6th weeks of radiotherapy and 4 weeks after the radiotherapy. Mouthrinse samples were analyzed for calprotectin and lactoferrin using commercial ELISA kits.
Calprotectin levels increased significantly during radiotherapy ( = 0.022). Both markers, lactoferrin ( = 0.011) and calprotectin ( = 0.006), decreased significantly after the treatment.
Present study results may suggest that the elevations in calprotectin and lactoferrin levels during radiotherapy reflect the increased and emerging inflammatory environment in the oral cavity, thus may increase the risk of periodontal disease initiation or progression.
乳铁蛋白是一种铁结合糖蛋白，钙卫蛋白是一种钙结合蛋白，它们是炎症的敏感标志物，在前列腺癌患者放疗期间其粪便水平会升高。在此背景下，我们分析了头颈癌患者放疗前、放疗期间和放疗后的漱口水钙卫蛋白和乳铁蛋白水平。
本研究纳入了20例计划对头颈部区域进行放疗的癌症患者（平均年龄55.85±15.01岁，80%为男性）。在放疗前、放疗第3周和第6周以及放疗后4周收集漱口水样本。使用商用ELISA试剂盒分析漱口水样本中的钙卫蛋白和乳铁蛋白。
放疗期间钙卫蛋白水平显著升高（P = 0.022）。治疗后，乳铁蛋白（P = 0.011）和钙卫蛋白（P = 0.006）这两种标志物均显著下降。
本研究结果可能表明，放疗期间钙卫蛋白和乳铁蛋白水平的升高反映了口腔中炎症环境的增加和出现，从而可能增加牙周疾病发生或进展的风险。
