Kunikullaya Ubrangala Kirthana, Kunnavil Radhika, Sanjeeva Vernekar Mamta, Goturu Jaisri, Prakash V S, Murthy Nandagudi Srinivasa
Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, F-35000 Rennes, France.
The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, 6229 ER Maastricht, The Netherlands.
Eur J Investig Health Psychol Educ. 2022 Oct 19;12(10):1535-1558. doi: 10.3390/ejihpe12100108.
Among the different anthropogenic stimuli humans are exposed to, the psychological and cardiovascular effects of auditory stimuli are less understood. This study aims to explore the possible range of change after a single session of auditory stimulation with three different ‘Modes’ of musical stimuli (MS) on anxiety, biomarkers of stress, and cardiovascular parameters among healthy young individuals. In this randomized control trial, 140 healthy young adults, aged 18−30 years, were randomly assigned to three MS groups (Mode/Raga Miyan ki Todi, Malkauns, and Puriya) and one control group (natural sounds). The outcome measurements of the State-Trait Anxiety Inventory, salivary alpha-amylase (sAA), salivary cortisol (sCort), blood pressure, and heart rate variability (HRV) were collected at three time points: before (M1), during (M2), and after the intervention (M3). State anxiety was reduced significantly with raga Puriya (p = 0.018), followed by raga Malkauns and raga Miyan Ki Todi. All the groups showed a significant reduction in sAA. Raga Miyan ki Todi and Puriya caused an arousal effect (as evidenced by HRV) during the intervention and significant relaxation after the intervention (both p < 0.005). Raga Malkauns and the control group had a sustained rise in parasympathetic activity over 30 min. Future studies should try to use other modes and features to develop a better scientific foundation for the use of Indian music in medicine.
在人类所接触到的不同人为刺激中，听觉刺激对心理和心血管的影响了解较少。本研究旨在探讨在健康年轻个体中，单次使用三种不同“模式”的音乐刺激（MS）进行听觉刺激后，焦虑、压力生物标志物和心血管参数可能的变化范围。在这项随机对照试验中，140名年龄在18至30岁的健康年轻成年人被随机分配到三个MS组（模式/拉格《米亚恩的托迪》、《马尔康斯》和《普里亚》）和一个对照组（自然声音）。在三个时间点收集状态-特质焦虑量表、唾液α-淀粉酶（sAA）、唾液皮质醇（sCort）、血压和心率变异性（HRV）的结果测量值：干预前（M1）、干预期间（M2）和干预后（M3）。使用拉格《普里亚》后，状态焦虑显著降低（p = 0.018），其次是拉格《马尔康斯》和拉格《米亚恩的托迪》。所有组的sAA均显著降低。拉格《米亚恩的托迪》和《普里亚》在干预期间引起了唤醒效应（以HRV为证），干预后显著放松（均p < 0.005）。拉格《马尔康斯》组和对照组在30分钟内副交感神经活动持续上升。未来的研究应尝试使用其他模式和特征，为印度音乐在医学中的应用建立更好的科学基础。
