Facciolà Alessio, D'Amato Smeralda, Calimeri Sebastiano, Giudice Daniela Lo, Micali Cristina, Russotto Ylenia, Venanzi Rullo Emmanuele, Nunnari Giuseppe, Squeri Raffaele, Pellicanò Giovanni Francesco
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy.
Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy.
Infect Dis Rep. 2022 Oct 17;14(5):784-793. doi: 10.3390/idr14050080.
HIV/AIDS is considered a risk factor for increased mortality due to COVID-19. For this reason, it is essential to include this population in vaccination campaigns. Studies found that antibodies are lower in HIV+ patients than in healthy individuals. The aim of this study was to assess the immune response in a cohort of people living with HIV/AIDS (PLWH) vaccinated with COVID-19 vaccination in order to evaluate the role played by the HIV infection in the efficacy of this vaccine. We carried out a cross-sectional study in the period April-September 2021, involving a cohort of PLWH and a cohort of HIV-uninfected people as the control group. The efficacy of vaccination was high in both groups despite a slight and not significant difference between them. However, important differences were found according to the intensity of the immune response. Specifically, while in the HIV+ group almost a quarter of people had a low response, it is important to remark that the control group had only a high or intermediate response after vaccination. Our results suggest the high efficacy of the mRNA COVID-19 vaccine in PLWH and the importance to vaccinate against COVID-19 in these patients in order to increase their protection.
人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）被认为是导致因2019冠状病毒病（COVID-19）死亡风险增加的一个因素。因此，将这一人群纳入疫苗接种活动至关重要。研究发现，HIV阳性患者体内的抗体水平低于健康个体。本研究的目的是评估一组接受COVID-19疫苗接种的HIV/AIDS患者（PLWH）的免疫反应，以评估HIV感染对该疫苗效力的影响。我们在2021年4月至9月期间开展了一项横断面研究，涉及一组PLWH和一组未感染HIV的人群作为对照组。两组的疫苗接种效力都很高，尽管两组之间存在轻微且不显著的差异。然而，根据免疫反应的强度发现了重要差异。具体而言，虽然在HIV阳性组中近四分之一的人反应较低，但需要指出的是，对照组在接种疫苗后只有高反应或中等反应。我们的结果表明，mRNA COVID-19疫苗在PLWH中具有高效力，并且为这些患者接种COVID-19疫苗以增强其保护作用非常重要。
